In vitro and in vivo activities of LJC10,627, a new carbapenem with stability to dehydropeptidase I

P. J. Petersen, N. V. Jacobus, W. J. Weiss, R. T. Testa

Research output: Contribution to journalArticle

75 Scopus citations

Abstract

The activity of LJC 10,627 was compared with the activities of imipenem and other antibiotics. LJC 10,627 was more active against most members of the family Enterobacteriaceae, Pseudomonas spp., and Acinetobacter spp. but slightly less active than imipenem against staphylococci and streptococci. LJC10,627 showed stability to mouse dehydropeptidase I and was more effective in vivo than imipenem plus cilastatin against gramnegative bacterial infections and as effective against staphylococcal infections.

Original languageEnglish
Pages (from-to)203-207
Number of pages5
JournalAntimicrobial agents and chemotherapy
Volume35
Issue number1
DOIs
StatePublished - 1991

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