In vitro activities of an investigational quinolone, glycylcycline, glycopeptide, streptogramin, and oxazolidinone tested alone and in combinations against vancomycin-resistant Enterococcus faecium

Renee Claude Mercier, Scott R. Penzak, Michael J. Rybak

Research output: Contribution to journalArticle

33 Scopus citations


We evaluated the in vitro activities of clinafloxacin, CL331,002, LY333328, quinupristin dalfopristin, and eperezolid (formerly known as U- 100,592) against four strains of enterococci. All regimens tested resulted in the growth inhibition of each isolate. Against the three clinafloxacin- susceptible strains, clinafloxacin tested alone was the most active treatment, decreasing the bacterial inoculum by more than 3 log10 CFU/ml after 24 h in time-kill curve studies.

Original languageEnglish
Pages (from-to)2573-2575
Number of pages3
JournalAntimicrobial agents and chemotherapy
Issue number11
Publication statusPublished - 1 Nov 1997


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