TY - JOUR
T1 - Impact of aging immune system on neurodegeneration and potential immunotherapies
AU - Liang, Zhanfeng
AU - Zhao, Yang
AU - Ruan, Linhui
AU - Zhu, Linnan
AU - Jin, Kunlin
AU - Zhuge, Qichuan
AU - Su, Dong Ming
AU - Zhao, Yong
N1 - Funding Information:
We appreciated Dr. Aqeel Javeed for his careful reviewing our manuscript. This work was supported by grants from the National Natural Science Foundation for General and Key Programs ( 81130055 , 31470860 , Y.Z.; 81400954 , L.R.; 81371396 , Q.Z.), the Ministry of Science and Technology of China ( 2017YFA0105002 ), Knowledge Innovation Program of Chinese Academy of Sciences ( XDA04020202-19 , Y.Z.), The China Manned Space Flight Technology Project (TZ-1), and the CAS/SAFEA International Partnership Program for Creative Research Teams (Y.Z.).
Publisher Copyright:
© 2017 Elsevier Ltd
PY - 2017/10
Y1 - 2017/10
N2 - The interaction between the nervous and immune systems during aging is an area of avid interest, but many aspects remain unclear. This is due, not only to the complexity of the aging process, but also to a mutual dependency and reciprocal causation of alterations and diseases between both the nervous and immune systems. Aging of the brain drives whole body systemic aging, including aging-related changes of the immune system. In turn, the immune system aging, particularly immunosenescence and T cell aging initiated by thymic involution that are sources of chronic inflammation in the elderly (termed inflammaging), potentially induces brain aging and memory loss in a reciprocal manner. Therefore, immunotherapeutics including modulation of inflammation, vaccination, cellular immune therapies and “protective autoimmunity” provide promising approaches to rejuvenate neuroinflammatory disorders and repair brain injury. In this review, we summarize recent discoveries linking the aging immune system with the development of neurodegeneration. Additionally, we discuss potential rejuvenation strategies, focusing aimed at targeting the aging immune system in an effort to prevent acute brain injury and chronic neurodegeneration during aging.
AB - The interaction between the nervous and immune systems during aging is an area of avid interest, but many aspects remain unclear. This is due, not only to the complexity of the aging process, but also to a mutual dependency and reciprocal causation of alterations and diseases between both the nervous and immune systems. Aging of the brain drives whole body systemic aging, including aging-related changes of the immune system. In turn, the immune system aging, particularly immunosenescence and T cell aging initiated by thymic involution that are sources of chronic inflammation in the elderly (termed inflammaging), potentially induces brain aging and memory loss in a reciprocal manner. Therefore, immunotherapeutics including modulation of inflammation, vaccination, cellular immune therapies and “protective autoimmunity” provide promising approaches to rejuvenate neuroinflammatory disorders and repair brain injury. In this review, we summarize recent discoveries linking the aging immune system with the development of neurodegeneration. Additionally, we discuss potential rejuvenation strategies, focusing aimed at targeting the aging immune system in an effort to prevent acute brain injury and chronic neurodegeneration during aging.
KW - Aging
KW - Immune system
KW - Immunotherapy
KW - Inflammation
KW - Neurodegeneration
UR - http://www.scopus.com/inward/record.url?scp=85028355696&partnerID=8YFLogxK
U2 - 10.1016/j.pneurobio.2017.07.006
DO - 10.1016/j.pneurobio.2017.07.006
M3 - Review article
C2 - 28782588
AN - SCOPUS:85028355696
SN - 0301-0082
VL - 157
SP - 2
EP - 28
JO - Progress in Neurobiology
JF - Progress in Neurobiology
ER -