Immunoglobulin (gm and km) allotypes in the aymara of Chile and bolivia

R. Chakraborty, H. Gershowitz, R. E. Ferrell, S. A. Barton, W. J. Schull

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Immunoglobulin (Gm and Km) allotype and haplotype frequencies are presented for 1707 individuals from Northern Chile and Western Boliva, subdividing them by ethnicity and altitude of residence. The haplotype distributions of Gm as well as Km loci in these populations suggest that in almost all of the ethnicity×altitude subdivisions of this population considerable admixture of AmerIndian and Caucasian genes have occurred. The haplotype frequency heterogeneity and the analysis of departure from Hardy-Weinberg expectations demonstrate that while some local variation in haplotype frequencies at the Gm and Km loci exists in this region, there is no clear evidence suggesting that the pattern of variation is due to an adaptation to the hypoxia of altitude. We conclude that such differences in haplotype frequencies are probably due to random genetic drift and differential admixture of AmerIndian and Caucasian genes that have occurred in the past.

Original languageEnglish
Pages (from-to)533-543
Number of pages11
JournalAnnals of Human Biology
Volume12
Issue number6
DOIs
StatePublished - 1 Jan 1985

Fingerprint Dive into the research topics of 'Immunoglobulin (gm and km) allotypes in the aymara of Chile and bolivia'. Together they form a unique fingerprint.

  • Cite this

    Chakraborty, R., Gershowitz, H., Ferrell, R. E., Barton, S. A., & Schull, W. J. (1985). Immunoglobulin (gm and km) allotypes in the aymara of Chile and bolivia. Annals of Human Biology, 12(6), 533-543. https://doi.org/10.1080/03014468500008111