TY - JOUR
T1 - Immunoglobulin (gm and km) allotypes in nine endogamous groups of west bengal, India
AU - Chakraborty, R.
AU - Walter, H.
AU - Sauber, P.
AU - Mukherjee, B. N.
AU - Malhotra, K. C.
AU - Banerjee, S.
AU - Roy, M.
N1 - Funding Information:
The data collected during this project was funded by collaborative research funds from Deutsche Forschungsgemeinschaft (Wa 122-29/1) and the Indian Statistical
Funding Information:
Institute, Calcutta. Data analysis was supported by US Public Health Service Research Grants from the National Institutes of Health. We are grateful to Professor B.P. Adhikari for his encouragement and guidance during the conduct of the survey. Discussions with Drs D. Hewett-Emmett and T. C. Douglas regarding the molecular basis of the IgG gene cluster are greatly appreciated.
PY - 1987
Y1 - 1987
N2 - Blood samples from 898 individuals of nine endogamous groups of West Bengal, India were typed for determining the haplotypic structure in the γlight chain (Gm) and x-light chain (Km) of immunoglobulin (IgG). The Gm haplotype frequencies detected by Glm (1), Glm (2) and G3m (5) markers suggest that in this eastern state of India there is considerable variation of frequencies of the typical Mongoloid haplotype Gm1,5, which shows a high incidence in Rajbanshi, Rabha, Garo and Lodha groups. On the contrary, this haplotype is probably absent in the high caste groups, Rarhi Brahmin and Vaidya, and is relatively infrequent in Jalia Kaibarta, a scheduled caste of the south-western part of the state. The Km1 allele is also high in frequency among Rajbanshi, Rabha, Garo and Munda in comparison with Rarhi Brahmin and Vaidya, suggesting the former four groups' strong Mongoloid affiliation. This survey signifies that there is considerable variation in the extent of Mongoloid admixture in Bengali populations. Such admixture is not restricted in specific social class either. It further demonstrates that heterogeneity of the genetic structure of Bengali populations do not correspond to the present social ranking on the basis of caste hierarchy.
AB - Blood samples from 898 individuals of nine endogamous groups of West Bengal, India were typed for determining the haplotypic structure in the γlight chain (Gm) and x-light chain (Km) of immunoglobulin (IgG). The Gm haplotype frequencies detected by Glm (1), Glm (2) and G3m (5) markers suggest that in this eastern state of India there is considerable variation of frequencies of the typical Mongoloid haplotype Gm1,5, which shows a high incidence in Rajbanshi, Rabha, Garo and Lodha groups. On the contrary, this haplotype is probably absent in the high caste groups, Rarhi Brahmin and Vaidya, and is relatively infrequent in Jalia Kaibarta, a scheduled caste of the south-western part of the state. The Km1 allele is also high in frequency among Rajbanshi, Rabha, Garo and Munda in comparison with Rarhi Brahmin and Vaidya, suggesting the former four groups' strong Mongoloid affiliation. This survey signifies that there is considerable variation in the extent of Mongoloid admixture in Bengali populations. Such admixture is not restricted in specific social class either. It further demonstrates that heterogeneity of the genetic structure of Bengali populations do not correspond to the present social ranking on the basis of caste hierarchy.
UR - http://www.scopus.com/inward/record.url?scp=0023267983&partnerID=8YFLogxK
U2 - 10.1080/03014468700006882
DO - 10.1080/03014468700006882
M3 - Article
C2 - 3111344
AN - SCOPUS:0023267983
SN - 0301-4460
VL - 14
SP - 155
EP - 167
JO - Annals of Human Biology
JF - Annals of Human Biology
IS - 2
ER -