Abstract
Current anti-angiogenic therapy for cancer is based mainly on inhibition of the vascular endothelial growth factor pathway. However, due to the transient and only modest benefit from such therapy, additional approaches are needed. Deregulation of microRNAs (miRNAs) has been demonstrated to be involved in tumor angiogenesis and offers opportunities for a new therapeutic approach. However, effective miRNA-delivery systems are needed for such approaches to be successful. In this study, miRNA profiling of patient data sets, along with in vitro and in vivo experiments, revealed that miR-204-5p could promote angiogenesis in ovarian tumors through THBS1. By binding with scavenger receptor class B type 1 (SCARB1), reconstituted high-density lipoprotein–nanoparticles (rHDL–NPs) were effective in delivering miR-204-5p inhibitor (miR-204-5p-inh) to tumor sites to suppress tumor growth. These results offer a new understanding of miR-204-5p in regulating tumor angiogenesis.
| Original language | English |
|---|---|
| Pages (from-to) | 6095-6108 |
| Number of pages | 14 |
| Journal | Oncogene |
| Volume | 38 |
| Issue number | 33 |
| DOIs | |
| State | Published - 15 Aug 2019 |
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Identifying and targeting angiogenesis-related microRNAs in ovarian cancer. / Chen, Xiuhui; Mangala, Lingegowda S.; Mooberry, Linda; Bayraktar, Emine; Dasari, Santosh K.; Ma, Shaolin; Ivan, Cristina; Court, Karem A.; Rodriguez-Aguayo, Cristian; Bayraktar, Recep; Raut, Sangram; Sabnis, Nirupama; Kong, Xianchao; Yang, Xianbin; Lopez-Berestein, Gabriel; Lacko, Andras G.; Sood, Anil K.
In: Oncogene, Vol. 38, No. 33, 15.08.2019, p. 6095-6108.Research output: Contribution to journal › Article
TY - JOUR
T1 - Identifying and targeting angiogenesis-related microRNAs in ovarian cancer
AU - Chen, Xiuhui
AU - Mangala, Lingegowda S.
AU - Mooberry, Linda
AU - Bayraktar, Emine
AU - Dasari, Santosh K.
AU - Ma, Shaolin
AU - Ivan, Cristina
AU - Court, Karem A.
AU - Rodriguez-Aguayo, Cristian
AU - Bayraktar, Recep
AU - Raut, Sangram
AU - Sabnis, Nirupama
AU - Kong, Xianchao
AU - Yang, Xianbin
AU - Lopez-Berestein, Gabriel
AU - Lacko, Andras G.
AU - Sood, Anil K.
PY - 2019/8/15
Y1 - 2019/8/15
N2 - Current anti-angiogenic therapy for cancer is based mainly on inhibition of the vascular endothelial growth factor pathway. However, due to the transient and only modest benefit from such therapy, additional approaches are needed. Deregulation of microRNAs (miRNAs) has been demonstrated to be involved in tumor angiogenesis and offers opportunities for a new therapeutic approach. However, effective miRNA-delivery systems are needed for such approaches to be successful. In this study, miRNA profiling of patient data sets, along with in vitro and in vivo experiments, revealed that miR-204-5p could promote angiogenesis in ovarian tumors through THBS1. By binding with scavenger receptor class B type 1 (SCARB1), reconstituted high-density lipoprotein–nanoparticles (rHDL–NPs) were effective in delivering miR-204-5p inhibitor (miR-204-5p-inh) to tumor sites to suppress tumor growth. These results offer a new understanding of miR-204-5p in regulating tumor angiogenesis.
AB - Current anti-angiogenic therapy for cancer is based mainly on inhibition of the vascular endothelial growth factor pathway. However, due to the transient and only modest benefit from such therapy, additional approaches are needed. Deregulation of microRNAs (miRNAs) has been demonstrated to be involved in tumor angiogenesis and offers opportunities for a new therapeutic approach. However, effective miRNA-delivery systems are needed for such approaches to be successful. In this study, miRNA profiling of patient data sets, along with in vitro and in vivo experiments, revealed that miR-204-5p could promote angiogenesis in ovarian tumors through THBS1. By binding with scavenger receptor class B type 1 (SCARB1), reconstituted high-density lipoprotein–nanoparticles (rHDL–NPs) were effective in delivering miR-204-5p inhibitor (miR-204-5p-inh) to tumor sites to suppress tumor growth. These results offer a new understanding of miR-204-5p in regulating tumor angiogenesis.
UR - http://www.scopus.com/inward/record.url?scp=85068690084&partnerID=8YFLogxK
U2 - 10.1038/s41388-019-0862-y
DO - 10.1038/s41388-019-0862-y
M3 - Article
C2 - 31289363
AN - SCOPUS:85068690084
VL - 38
SP - 6095
EP - 6108
JO - Oncogene
JF - Oncogene
SN - 0950-9232
IS - 33
ER -