Identifying and targeting angiogenesis-related microRNAs in ovarian cancer

Xiuhui Chen; Lingegowda S. Mangala; Linda Mooberry; Emine Bayraktar; Santosh K. Dasari; Shaolin Ma; Cristina Ivan; Karem A. Court; Cristian Rodriguez-Aguayo; Recep Bayraktar; Sangram Raut; Nirupama Sabnis; Xianchao Kong; Xianbin Yang; Gabriel Lopez-Berestein; Andras G. Lacko; Anil K. Sood

doi:10.1038/s41388-019-0862-y

Identifying and targeting angiogenesis-related microRNAs in ovarian cancer

Xiuhui Chen, Lingegowda S. Mangala, Linda Mooberry, Emine Bayraktar, Santosh K. Dasari, Shaolin Ma, Cristina Ivan, Karem A. Court, Cristian Rodriguez-Aguayo, Recep Bayraktar, Sangram Raut, Nirupama Sabnis, Xianchao Kong, Xianbin Yang, Gabriel Lopez-Berestein, Andras G. Lacko, Anil K. Sood

Research output: Contribution to journal › Article

3 Scopus citations

Abstract

Current anti-angiogenic therapy for cancer is based mainly on inhibition of the vascular endothelial growth factor pathway. However, due to the transient and only modest benefit from such therapy, additional approaches are needed. Deregulation of microRNAs (miRNAs) has been demonstrated to be involved in tumor angiogenesis and offers opportunities for a new therapeutic approach. However, effective miRNA-delivery systems are needed for such approaches to be successful. In this study, miRNA profiling of patient data sets, along with in vitro and in vivo experiments, revealed that miR-204-5p could promote angiogenesis in ovarian tumors through THBS1. By binding with scavenger receptor class B type 1 (SCARB1), reconstituted high-density lipoprotein–nanoparticles (rHDL–NPs) were effective in delivering miR-204-5p inhibitor (miR-204-5p-inh) to tumor sites to suppress tumor growth. These results offer a new understanding of miR-204-5p in regulating tumor angiogenesis.

Original language	English
Pages (from-to)	6095-6108
Number of pages	14
Journal	Oncogene
Volume	38
Issue number	33
DOIs	https://doi.org/10.1038/s41388-019-0862-y
State	Published - 15 Aug 2019

Fingerprint

Cite this

Chen, X., Mangala, L. S., Mooberry, L., Bayraktar, E., Dasari, S. K., Ma, S., Ivan, C., Court, K. A., Rodriguez-Aguayo, C., Bayraktar, R., Raut, S., Sabnis, N., Kong, X., Yang, X., Lopez-Berestein, G., Lacko, A. G., & Sood, A. K. (2019). Identifying and targeting angiogenesis-related microRNAs in ovarian cancer. Oncogene, 38(33), 6095-6108. https://doi.org/10.1038/s41388-019-0862-y

Chen, Xiuhui ; Mangala, Lingegowda S. ; Mooberry, Linda ; Bayraktar, Emine ; Dasari, Santosh K. ; Ma, Shaolin ; Ivan, Cristina ; Court, Karem A. ; Rodriguez-Aguayo, Cristian ; Bayraktar, Recep ; Raut, Sangram ; Sabnis, Nirupama ; Kong, Xianchao ; Yang, Xianbin ; Lopez-Berestein, Gabriel ; Lacko, Andras G. ; Sood, Anil K. / Identifying and targeting angiogenesis-related microRNAs in ovarian cancer. In: Oncogene. 2019 ; Vol. 38, No. 33. pp. 6095-6108.

@article{6367515fd9454ca092ace1b78689e114,

title = "Identifying and targeting angiogenesis-related microRNAs in ovarian cancer",

abstract = "Current anti-angiogenic therapy for cancer is based mainly on inhibition of the vascular endothelial growth factor pathway. However, due to the transient and only modest benefit from such therapy, additional approaches are needed. Deregulation of microRNAs (miRNAs) has been demonstrated to be involved in tumor angiogenesis and offers opportunities for a new therapeutic approach. However, effective miRNA-delivery systems are needed for such approaches to be successful. In this study, miRNA profiling of patient data sets, along with in vitro and in vivo experiments, revealed that miR-204-5p could promote angiogenesis in ovarian tumors through THBS1. By binding with scavenger receptor class B type 1 (SCARB1), reconstituted high-density lipoprotein–nanoparticles (rHDL–NPs) were effective in delivering miR-204-5p inhibitor (miR-204-5p-inh) to tumor sites to suppress tumor growth. These results offer a new understanding of miR-204-5p in regulating tumor angiogenesis.",

author = "Xiuhui Chen and Mangala, {Lingegowda S.} and Linda Mooberry and Emine Bayraktar and Dasari, {Santosh K.} and Shaolin Ma and Cristina Ivan and Court, {Karem A.} and Cristian Rodriguez-Aguayo and Recep Bayraktar and Sangram Raut and Nirupama Sabnis and Xianchao Kong and Xianbin Yang and Gabriel Lopez-Berestein and Lacko, {Andras G.} and Sood, {Anil K.}",

year = "2019",

month = aug

day = "15",

doi = "10.1038/s41388-019-0862-y",

language = "English",

volume = "38",

pages = "6095--6108",

journal = "Oncogene",

issn = "0950-9232",

publisher = "Nature Publishing Group",

number = "33",

}

Identifying and targeting angiogenesis-related microRNAs in ovarian cancer. / Chen, Xiuhui; Mangala, Lingegowda S.; Mooberry, Linda; Bayraktar, Emine; Dasari, Santosh K.; Ma, Shaolin; Ivan, Cristina; Court, Karem A.; Rodriguez-Aguayo, Cristian; Bayraktar, Recep; Raut, Sangram; Sabnis, Nirupama; Kong, Xianchao; Yang, Xianbin; Lopez-Berestein, Gabriel; Lacko, Andras G.; Sood, Anil K.

In: Oncogene, Vol. 38, No. 33, 15.08.2019, p. 6095-6108.

Research output: Contribution to journal › Article

TY - JOUR

T1 - Identifying and targeting angiogenesis-related microRNAs in ovarian cancer

AU - Chen, Xiuhui

AU - Mangala, Lingegowda S.

AU - Mooberry, Linda

AU - Bayraktar, Emine

AU - Dasari, Santosh K.

AU - Ma, Shaolin

AU - Ivan, Cristina

AU - Court, Karem A.

AU - Rodriguez-Aguayo, Cristian

AU - Bayraktar, Recep

AU - Raut, Sangram

AU - Sabnis, Nirupama

AU - Kong, Xianchao

AU - Yang, Xianbin

AU - Lopez-Berestein, Gabriel

AU - Lacko, Andras G.

AU - Sood, Anil K.

PY - 2019/8/15

Y1 - 2019/8/15

N2 - Current anti-angiogenic therapy for cancer is based mainly on inhibition of the vascular endothelial growth factor pathway. However, due to the transient and only modest benefit from such therapy, additional approaches are needed. Deregulation of microRNAs (miRNAs) has been demonstrated to be involved in tumor angiogenesis and offers opportunities for a new therapeutic approach. However, effective miRNA-delivery systems are needed for such approaches to be successful. In this study, miRNA profiling of patient data sets, along with in vitro and in vivo experiments, revealed that miR-204-5p could promote angiogenesis in ovarian tumors through THBS1. By binding with scavenger receptor class B type 1 (SCARB1), reconstituted high-density lipoprotein–nanoparticles (rHDL–NPs) were effective in delivering miR-204-5p inhibitor (miR-204-5p-inh) to tumor sites to suppress tumor growth. These results offer a new understanding of miR-204-5p in regulating tumor angiogenesis.

AB - Current anti-angiogenic therapy for cancer is based mainly on inhibition of the vascular endothelial growth factor pathway. However, due to the transient and only modest benefit from such therapy, additional approaches are needed. Deregulation of microRNAs (miRNAs) has been demonstrated to be involved in tumor angiogenesis and offers opportunities for a new therapeutic approach. However, effective miRNA-delivery systems are needed for such approaches to be successful. In this study, miRNA profiling of patient data sets, along with in vitro and in vivo experiments, revealed that miR-204-5p could promote angiogenesis in ovarian tumors through THBS1. By binding with scavenger receptor class B type 1 (SCARB1), reconstituted high-density lipoprotein–nanoparticles (rHDL–NPs) were effective in delivering miR-204-5p inhibitor (miR-204-5p-inh) to tumor sites to suppress tumor growth. These results offer a new understanding of miR-204-5p in regulating tumor angiogenesis.

UR - http://www.scopus.com/inward/record.url?scp=85068690084&partnerID=8YFLogxK

U2 - 10.1038/s41388-019-0862-y

DO - 10.1038/s41388-019-0862-y

M3 - Article

C2 - 31289363

AN - SCOPUS:85068690084

VL - 38

SP - 6095

EP - 6108

JO - Oncogene

JF - Oncogene

SN - 0950-9232

IS - 33

ER -

Access to Document

10.1038/s41388-019-0862-y

Link to publication in Scopus