Hypoxia-inducible factor-1 and neuroglobin expression

Bryan Haines, Marco Demaria, Xiao Mao, Lin Xie, Judith Campisi, Kunlin Jin, David A. Greenberg

Research output: Contribution to journalComment/debate

41 Scopus citations

Abstract

Neuroglobin (Ngb) is a hypoxia-inducible protein with cytoprotective effects in animal models of stroke, Alzheimer's disease, and related disorders, but the molecular mechanisms involved in its induction are unknown. We tested the hypothesis that hypoxia-inducible factor-1 (HIF-1) regulates Ngb levels, using shRNA-mediated knockdown and lentiviral vector-mediated overexpression of the HIF-1α subunit, in cultured neural (HN33) cells. HIF-1α knockdown decreased and HIF-1α overexpression increased Ngb levels, consistent with a connection between HIF-1 and Ngb induction. These findings may have implications for understanding the hypoxia-response repertoire of neural cells and devising therapeutic strategies for neurologic disorders.

Original languageEnglish
Pages (from-to)137-140
Number of pages4
JournalNeuroscience letters
Volume514
Issue number2
DOIs
StatePublished - 18 Apr 2012

Keywords

  • Hypoxia
  • Hypoxia-inducible factor-1
  • Neuroglobin
  • Stroke

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    Haines, B., Demaria, M., Mao, X., Xie, L., Campisi, J., Jin, K., & Greenberg, D. A. (2012). Hypoxia-inducible factor-1 and neuroglobin expression. Neuroscience letters, 514(2), 137-140. https://doi.org/10.1016/j.neulet.2012.01.080