Hyperpolarized 89Y complexes as pH sensitive NMR probes

Ashish K. Jindal; Matthew E. Merritt; Eul Hyun Suh; Craig R. Malloy; A. Dean Sherry; Zoltán Kovács

doi:10.1021/ja910278e

Hyperpolarized ⁸⁹Y complexes as pH sensitive NMR probes

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Abstract

(Chemical Presented)Hyperpolarization can increase the sensitivity of NMR/MRI experiments, but the primary limitation is the T₁ decay of magnetization. Due to its long T₁, the hyperpolarized ⁸⁹Y nucleus makes an excellent candidate as an in vivo spectroscopy/imaging probe. Here we report the ⁸⁹Y chemical shift dependence upon pH for two hyperpolarized ⁸⁹Y(III) complexes and demonstrate how such complexes can be used as sensitive spectroscopy/imaging agents to measure pH.

Original language	English
Pages (from-to)	1784-1785
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	132
Issue number	6
DOIs	https://doi.org/10.1021/ja910278e
State	Published - 2010

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title = "Hyperpolarized 89Y complexes as pH sensitive NMR probes",

abstract = "(Chemical Presented)Hyperpolarization can increase the sensitivity of NMR/MRI experiments, but the primary limitation is the T1 decay of magnetization. Due to its long T1, the hyperpolarized 89Y nucleus makes an excellent candidate as an in vivo spectroscopy/imaging probe. Here we report the 89Y chemical shift dependence upon pH for two hyperpolarized 89Y(III) complexes and demonstrate how such complexes can be used as sensitive spectroscopy/imaging agents to measure pH.",

author = "Jindal, {Ashish K.} and Merritt, {Matthew E.} and Suh, {Eul Hyun} and Malloy, {Craig R.} and Sherry, {A. Dean} and Zolt{\'a}n Kov{\'a}cs",

year = "2010",

doi = "10.1021/ja910278e",

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journal = "Journal of the American Chemical Society",

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T1 - Hyperpolarized 89Y complexes as pH sensitive NMR probes

AU - Jindal, Ashish K.

AU - Merritt, Matthew E.

AU - Suh, Eul Hyun

AU - Malloy, Craig R.

AU - Sherry, A. Dean

AU - Kovács, Zoltán

PY - 2010

Y1 - 2010

N2 - (Chemical Presented)Hyperpolarization can increase the sensitivity of NMR/MRI experiments, but the primary limitation is the T1 decay of magnetization. Due to its long T1, the hyperpolarized 89Y nucleus makes an excellent candidate as an in vivo spectroscopy/imaging probe. Here we report the 89Y chemical shift dependence upon pH for two hyperpolarized 89Y(III) complexes and demonstrate how such complexes can be used as sensitive spectroscopy/imaging agents to measure pH.

AB - (Chemical Presented)Hyperpolarization can increase the sensitivity of NMR/MRI experiments, but the primary limitation is the T1 decay of magnetization. Due to its long T1, the hyperpolarized 89Y nucleus makes an excellent candidate as an in vivo spectroscopy/imaging probe. Here we report the 89Y chemical shift dependence upon pH for two hyperpolarized 89Y(III) complexes and demonstrate how such complexes can be used as sensitive spectroscopy/imaging agents to measure pH.

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U2 - 10.1021/ja910278e

DO - 10.1021/ja910278e

M3 - Article

C2 - 20102196

AN - SCOPUS:77249155189

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JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 6

ER -

Hyperpolarized ⁸⁹Y complexes as pH sensitive NMR probes

Abstract

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