@article{5be793ada8a14af0ae1a59c855d85d78,
title = "Hydrophobic acetal and ketal derivatives of mannopeptimycin-α and desmethylhexahydromannopeptimycin-α: Semisynthetic glycopeptides with potent activity against Gram-positive bacteria",
abstract = "The effect of introducing hydrophobic groups onto the disaccharide portion of the mannopeptimycins has been examined. Under acid-catalyzed conditions dimethyl acetals and ketals react on the terminal mannose of the disaccharide moiety of mannopeptimycin-α and the cyclohexylalanyl analogue 2. The preferentially formed monofunctionalized 4,6-acetals and -ketals display potent antibacterial activities against Gram-positive microorganisms, including MRSA, PRSP, and VRE pathogens.",
author = "Dushin, {Russell G.} and Wang, {Ting Zhong} and Sum, {Phaik Eng} and Haiyin He and Sutherland, {Alan G.} and Ashcroft, {Joseph S.} and Graziani, {Edmund I.} and Koehn, {Frank E.} and Bradford, {Patricia A.} and Petersen, {Peter J.} and Wheless, {Karen L.} and David How and Nancy Torres and Lenoy, {Eileen B.} and Weiss, {William J.} and Lang, {Stanley A.} and Projan, {Steven J.} and Shlaes, {David M.} and Mansour, {Tarek S.}",
year = "2004",
month = jul,
day = "1",
doi = "10.1021/jm049765y",
language = "English",
volume = "47",
pages = "3487--3490",
journal = "Journal of Medicinal Chemistry",
issn = "0022-2623",
publisher = "American Chemical Society",
number = "14",
}