@article{1b87928a80854ec58cfdde4b7e13ae26,
title = "Hybrid resistance: ‗Negative{\textquoteleft} and ‗positive{\textquoteleft} signaling of murine natural killer cells",
abstract = "Murine NK cells can reject allogenic or parental-strain bone marrow cells (BMC) in vivo and can lyse T lymphobasts in vitro. The ‗missing self{\textquoteleft} hypothesis states that absence or presence of ‗negative signals{\textquoteleft} from target cell class I antigens (Ag) to NK receptors determines whether or not lysis occurs. Indeed, lysis of parental-strain basts by purified F1 NK cell subsets occurred only in the presence of anti-receptor antibodies. Evidence for ‗positive signaling{\textquoteleft} to NK cells by class I Ag indudes rejection of D8 (Dd) transgene to B6) BMC by B6 hosts. The outcome of other BMC transplants ccntradict the missing self idea, because donors with identical class I Ag differ in compatibility with certain hosts. Perhaps class I Ag-NK cell receptor interactions dominate over other target-NK cell interactions. These interactions are usually ‗negative{\textquoteleft} but can be ‗positive{\textquoteleft}.",
keywords = "Class I molecules, Lysis of lymphoblasts, Marrow grafts, NK receptors",
author = "Michael Bennett and Yu, {Y. Y.Lawrence} and Earl Stoneman and Rembecki, {Richard M.} and Mathew, {Porunelloor A.} and Lindahl, {Kirsten Fischer} and Vinay Kumar",
note = "Funding Information: This work was supported by grants CA36922, CA36921, CA09082 and AI35401 from the National Institutes of Health and a grant from the Texas Department of Ladies Auxiliary, Veterans of Foreign Wars. We thank our colleagues Chella David, Michael J. Siciliano, Edward Wake-land, Carla Aldrich, Bruce Blazar, Lorraine Flaherty, James Forman, Katharina C. Bl{\"o}mer, Thomas D{\textquoteright}Orazio and David Stenoien for participation in some of the studies described, and we thank Silvio and Maria Pe{\~n}a, Margaretan Stolfo, Henry Taylor and Annie Eubanks for excellent breeding and caring of mice used in these experiments.",
year = "1995",
doi = "10.1006/smim.1995.0016",
language = "English",
volume = "7",
pages = "121--127",
journal = "Seminars in Immunology",
issn = "1044-5323",
publisher = "Academic Press Inc.",
number = "2",
}