Human natural killer cell receptor 2B4 (CD244) down-regulates its own expression by reduced promoter activity at an Ets element

Stephen O. Mathew, Swapnil V. Vaidya, Jong R. Kim, Porunelloor Mathew

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

2B4 (CD244), a member of the CD2 subset of the immunoglobulin superfamily, is important for stimulating human natural killer (NK) cell cytotoxicity and cytokine production. It is expressed on all NK cells, a subpopulation of T cells, monocytes, basophils and eosinophils. 2B4 interaction with its ligand CD48 regulates NK, T and B lymphocyte functions and thus plays a central role in various immune responses. Previous study indicated a role for AP-1 and Ets in the transcription of the 2B4 gene. In this study we report that stimulation of NK cells through surface 2B4 down-regulates its own expression due to a reduction in the promoter activity at the Ets element. The down-regulation of 2B4 could be a mechanism to attenuate the co-stimulatory signal from 2B4--CD48 interactions.

Original languageEnglish
Pages (from-to)483-487
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume355
Issue number2
DOIs
StatePublished - 6 Apr 2007

Fingerprint

T-cells
Lymphocytes
Transcription Factor AP-1
Transcription
Cytotoxicity
Natural Killer Cells
Immunoglobulins
Down-Regulation
Genes
Cytokines
Ligands
T-Lymphocytes
Basophils
Eosinophils
Monocytes
B-Lymphocytes
human CD244 protein

Keywords

  • 2B4 promoter
  • Ets element
  • Natural killer (NK) cell
  • Transcription regulation

Cite this

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abstract = "2B4 (CD244), a member of the CD2 subset of the immunoglobulin superfamily, is important for stimulating human natural killer (NK) cell cytotoxicity and cytokine production. It is expressed on all NK cells, a subpopulation of T cells, monocytes, basophils and eosinophils. 2B4 interaction with its ligand CD48 regulates NK, T and B lymphocyte functions and thus plays a central role in various immune responses. Previous study indicated a role for AP-1 and Ets in the transcription of the 2B4 gene. In this study we report that stimulation of NK cells through surface 2B4 down-regulates its own expression due to a reduction in the promoter activity at the Ets element. The down-regulation of 2B4 could be a mechanism to attenuate the co-stimulatory signal from 2B4--CD48 interactions.",
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AU - Mathew, Stephen O.

AU - Vaidya, Swapnil V.

AU - Kim, Jong R.

AU - Mathew, Porunelloor

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AB - 2B4 (CD244), a member of the CD2 subset of the immunoglobulin superfamily, is important for stimulating human natural killer (NK) cell cytotoxicity and cytokine production. It is expressed on all NK cells, a subpopulation of T cells, monocytes, basophils and eosinophils. 2B4 interaction with its ligand CD48 regulates NK, T and B lymphocyte functions and thus plays a central role in various immune responses. Previous study indicated a role for AP-1 and Ets in the transcription of the 2B4 gene. In this study we report that stimulation of NK cells through surface 2B4 down-regulates its own expression due to a reduction in the promoter activity at the Ets element. The down-regulation of 2B4 could be a mechanism to attenuate the co-stimulatory signal from 2B4--CD48 interactions.

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