Homogeneity in mitochondrial DNA control region sequences in Swedish subpopulations

Andreas O. Tillmar, Michael Dewitt Coble, Thomas Wallerström, Gunilla Holmlund

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

In order to promote mitochondrial DNA (mtDNA) testing in Sweden we have typed 296 Swedish males, which will serve as a Swedish mtDNA frequency database. The tested males were taken from seven geographically different regions representing the contemporary Swedish population. The complete mtDNA control region was typed and the Swedish population was shown to have high haplotype diversity with a random match probability of 0.5%. Almost 47% of the tested samples belonged to haplogroup H and further haplogroup comparison with worldwide populations clustered the Swedish mtDNA data together with other European populations. AMOVA analysis of the seven Swedish subregions displayed no significant maternal substructure in Sweden (F ST∈=∈0. 002). Our conclusion from this study is that the typed Swedish individuals serve as good representatives for a Swedish forensic mtDNA database. Some caution should, however, be taken for individuals from the northernmost part of Sweden (provinces of Norrbotten and Lapland) due to specific demographic conditions. Furthermore, our analysis of a small sample set of a Swedish Saami population confirmed earlier findings that the Swedish Saami population is an outlier among European populations.

Original languageEnglish
Pages (from-to)91-98
Number of pages8
JournalInternational journal of legal medicine
Volume124
Issue number2
DOIs
StatePublished - 1 Mar 2010

Fingerprint

Mitochondrial DNA
Population
Sweden
Nucleic Acid Databases
Haplotypes
Mothers
Demography

Keywords

  • Control region
  • Demography
  • Mitochondrial DNA
  • Saami
  • Sweden

Cite this

Tillmar, Andreas O. ; Coble, Michael Dewitt ; Wallerström, Thomas ; Holmlund, Gunilla. / Homogeneity in mitochondrial DNA control region sequences in Swedish subpopulations. In: International journal of legal medicine. 2010 ; Vol. 124, No. 2. pp. 91-98.
@article{1ec197ab86c346a7b481e539c148f2c0,
title = "Homogeneity in mitochondrial DNA control region sequences in Swedish subpopulations",
abstract = "In order to promote mitochondrial DNA (mtDNA) testing in Sweden we have typed 296 Swedish males, which will serve as a Swedish mtDNA frequency database. The tested males were taken from seven geographically different regions representing the contemporary Swedish population. The complete mtDNA control region was typed and the Swedish population was shown to have high haplotype diversity with a random match probability of 0.5{\%}. Almost 47{\%} of the tested samples belonged to haplogroup H and further haplogroup comparison with worldwide populations clustered the Swedish mtDNA data together with other European populations. AMOVA analysis of the seven Swedish subregions displayed no significant maternal substructure in Sweden (F ST∈=∈0. 002). Our conclusion from this study is that the typed Swedish individuals serve as good representatives for a Swedish forensic mtDNA database. Some caution should, however, be taken for individuals from the northernmost part of Sweden (provinces of Norrbotten and Lapland) due to specific demographic conditions. Furthermore, our analysis of a small sample set of a Swedish Saami population confirmed earlier findings that the Swedish Saami population is an outlier among European populations.",
keywords = "Control region, Demography, Mitochondrial DNA, Saami, Sweden",
author = "Tillmar, {Andreas O.} and Coble, {Michael Dewitt} and Thomas Wallerstr{\"o}m and Gunilla Holmlund",
year = "2010",
month = "3",
day = "1",
doi = "10.1007/s00414-009-0354-7",
language = "English",
volume = "124",
pages = "91--98",
journal = "International Journal of Legal Medicine",
issn = "0937-9827",
publisher = "Springer Verlag",
number = "2",

}

Homogeneity in mitochondrial DNA control region sequences in Swedish subpopulations. / Tillmar, Andreas O.; Coble, Michael Dewitt; Wallerström, Thomas; Holmlund, Gunilla.

In: International journal of legal medicine, Vol. 124, No. 2, 01.03.2010, p. 91-98.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Homogeneity in mitochondrial DNA control region sequences in Swedish subpopulations

AU - Tillmar, Andreas O.

AU - Coble, Michael Dewitt

AU - Wallerström, Thomas

AU - Holmlund, Gunilla

PY - 2010/3/1

Y1 - 2010/3/1

N2 - In order to promote mitochondrial DNA (mtDNA) testing in Sweden we have typed 296 Swedish males, which will serve as a Swedish mtDNA frequency database. The tested males were taken from seven geographically different regions representing the contemporary Swedish population. The complete mtDNA control region was typed and the Swedish population was shown to have high haplotype diversity with a random match probability of 0.5%. Almost 47% of the tested samples belonged to haplogroup H and further haplogroup comparison with worldwide populations clustered the Swedish mtDNA data together with other European populations. AMOVA analysis of the seven Swedish subregions displayed no significant maternal substructure in Sweden (F ST∈=∈0. 002). Our conclusion from this study is that the typed Swedish individuals serve as good representatives for a Swedish forensic mtDNA database. Some caution should, however, be taken for individuals from the northernmost part of Sweden (provinces of Norrbotten and Lapland) due to specific demographic conditions. Furthermore, our analysis of a small sample set of a Swedish Saami population confirmed earlier findings that the Swedish Saami population is an outlier among European populations.

AB - In order to promote mitochondrial DNA (mtDNA) testing in Sweden we have typed 296 Swedish males, which will serve as a Swedish mtDNA frequency database. The tested males were taken from seven geographically different regions representing the contemporary Swedish population. The complete mtDNA control region was typed and the Swedish population was shown to have high haplotype diversity with a random match probability of 0.5%. Almost 47% of the tested samples belonged to haplogroup H and further haplogroup comparison with worldwide populations clustered the Swedish mtDNA data together with other European populations. AMOVA analysis of the seven Swedish subregions displayed no significant maternal substructure in Sweden (F ST∈=∈0. 002). Our conclusion from this study is that the typed Swedish individuals serve as good representatives for a Swedish forensic mtDNA database. Some caution should, however, be taken for individuals from the northernmost part of Sweden (provinces of Norrbotten and Lapland) due to specific demographic conditions. Furthermore, our analysis of a small sample set of a Swedish Saami population confirmed earlier findings that the Swedish Saami population is an outlier among European populations.

KW - Control region

KW - Demography

KW - Mitochondrial DNA

KW - Saami

KW - Sweden

UR - http://www.scopus.com/inward/record.url?scp=77649237045&partnerID=8YFLogxK

U2 - 10.1007/s00414-009-0354-7

DO - 10.1007/s00414-009-0354-7

M3 - Article

C2 - 19590886

AN - SCOPUS:77649237045

VL - 124

SP - 91

EP - 98

JO - International Journal of Legal Medicine

JF - International Journal of Legal Medicine

SN - 0937-9827

IS - 2

ER -