Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of Homer-related, synaptic proteins

Bo Xiao, Jian Cheng Tu, Ronald S. Petralia, Joseph P. Yuan, Andrew Doan, Christopher D. Breder, Alicia Ruggiero, Anthony A. Lanahan, Robert J. Wenthold, Paul F. Worley

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Abstract

Homer is a neuronal immediate early gene (IEG) that is enriched at excitatory synapses and binds group 1 metabotropic glutamate receptors (mGluRs). Here, we characterize a family of Homer-related proteins derived from three distinct genes. Like Homer IEG (now termed Homer la), all new members bind group 1 mGluRs. In contrast to Homer 1a, new members are constitutively expressed and encode a C-terminal coiled-coil (CC) domain that mediates self-multimerization. CC-Homers form natural complexes that cross- link mGluRs and are enriched at the postsynaptic density. Homer 1a does not multimerize and blocks the association of mGluRs with CC-Homer complexes. These observations support a model in which the dynamic expression of Homer la competes with constitutively expressed CC-Homers to modify synaptic mGluR properties.

Original languageEnglish
Pages (from-to)707-716
Number of pages10
JournalNeuron
Volume21
Issue number4
DOIs
StatePublished - 1 Jan 1998

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Metabotropic Glutamate Receptors
Immediate-Early Genes
Post-Synaptic Density
Proteins
Synapses
Genes
metabotropic glutamate receptor type 1
Homer Scaffolding Proteins

Cite this

Xiao, Bo ; Tu, Jian Cheng ; Petralia, Ronald S. ; Yuan, Joseph P. ; Doan, Andrew ; Breder, Christopher D. ; Ruggiero, Alicia ; Lanahan, Anthony A. ; Wenthold, Robert J. ; Worley, Paul F. / Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of Homer-related, synaptic proteins. In: Neuron. 1998 ; Vol. 21, No. 4. pp. 707-716.
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abstract = "Homer is a neuronal immediate early gene (IEG) that is enriched at excitatory synapses and binds group 1 metabotropic glutamate receptors (mGluRs). Here, we characterize a family of Homer-related proteins derived from three distinct genes. Like Homer IEG (now termed Homer la), all new members bind group 1 mGluRs. In contrast to Homer 1a, new members are constitutively expressed and encode a C-terminal coiled-coil (CC) domain that mediates self-multimerization. CC-Homers form natural complexes that cross- link mGluRs and are enriched at the postsynaptic density. Homer 1a does not multimerize and blocks the association of mGluRs with CC-Homer complexes. These observations support a model in which the dynamic expression of Homer la competes with constitutively expressed CC-Homers to modify synaptic mGluR properties.",
author = "Bo Xiao and Tu, {Jian Cheng} and Petralia, {Ronald S.} and Yuan, {Joseph P.} and Andrew Doan and Breder, {Christopher D.} and Alicia Ruggiero and Lanahan, {Anthony A.} and Wenthold, {Robert J.} and Worley, {Paul F.}",
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Xiao, B, Tu, JC, Petralia, RS, Yuan, JP, Doan, A, Breder, CD, Ruggiero, A, Lanahan, AA, Wenthold, RJ & Worley, PF 1998, 'Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of Homer-related, synaptic proteins', Neuron, vol. 21, no. 4, pp. 707-716. https://doi.org/10.1016/S0896-6273(00)80588-7

Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of Homer-related, synaptic proteins. / Xiao, Bo; Tu, Jian Cheng; Petralia, Ronald S.; Yuan, Joseph P.; Doan, Andrew; Breder, Christopher D.; Ruggiero, Alicia; Lanahan, Anthony A.; Wenthold, Robert J.; Worley, Paul F.

In: Neuron, Vol. 21, No. 4, 01.01.1998, p. 707-716.

Research output: Contribution to journalArticleResearchpeer-review

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