Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of Homer-related, synaptic proteins

Bo Xiao, Jian Cheng Tu, Ronald S. Petralia, Joseph P. Yuan, Andrew Doan, Christopher D. Breder, Alicia Ruggiero, Anthony A. Lanahan, Robert J. Wenthold, Paul F. Worley

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Abstract

Homer is a neuronal immediate early gene (IEG) that is enriched at excitatory synapses and binds group 1 metabotropic glutamate receptors (mGluRs). Here, we characterize a family of Homer-related proteins derived from three distinct genes. Like Homer IEG (now termed Homer la), all new members bind group 1 mGluRs. In contrast to Homer 1a, new members are constitutively expressed and encode a C-terminal coiled-coil (CC) domain that mediates self-multimerization. CC-Homers form natural complexes that cross- link mGluRs and are enriched at the postsynaptic density. Homer 1a does not multimerize and blocks the association of mGluRs with CC-Homer complexes. These observations support a model in which the dynamic expression of Homer la competes with constitutively expressed CC-Homers to modify synaptic mGluR properties.

Original languageEnglish
Pages (from-to)707-716
Number of pages10
JournalNeuron
Volume21
Issue number4
DOIs
StatePublished - Oct 1998

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Xiao, B., Tu, J. C., Petralia, R. S., Yuan, J. P., Doan, A., Breder, C. D., Ruggiero, A., Lanahan, A. A., Wenthold, R. J., & Worley, P. F. (1998). Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of Homer-related, synaptic proteins. Neuron, 21(4), 707-716. https://doi.org/10.1016/S0896-6273(00)80588-7