@article{52c1224be23c43a59cf28937548d82fd,
title = "Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of Homer-related, synaptic proteins",
abstract = "Homer is a neuronal immediate early gene (IEG) that is enriched at excitatory synapses and binds group 1 metabotropic glutamate receptors (mGluRs). Here, we characterize a family of Homer-related proteins derived from three distinct genes. Like Homer IEG (now termed Homer la), all new members bind group 1 mGluRs. In contrast to Homer 1a, new members are constitutively expressed and encode a C-terminal coiled-coil (CC) domain that mediates self-multimerization. CC-Homers form natural complexes that cross- link mGluRs and are enriched at the postsynaptic density. Homer 1a does not multimerize and blocks the association of mGluRs with CC-Homer complexes. These observations support a model in which the dynamic expression of Homer la competes with constitutively expressed CC-Homers to modify synaptic mGluR properties.",
author = "Bo Xiao and Tu, {Jian Cheng} and Petralia, {Ronald S.} and Yuan, {Joseph P.} and Andrew Doan and Breder, {Christopher D.} and Alicia Ruggiero and Lanahan, {Anthony A.} and Wenthold, {Robert J.} and Worley, {Paul F.}",
note = "Funding Information: We thank Dr. Y.-X. Wang for assistance in the immunogold immunocytochemistry, Maria Papapavlou for help with in situ hybridization, Patrick Burnett for help in preparation of subcellular fractions, Mitra Cowan of the JHH transgenic facility for assistance with animal breeding, and C.-Y. Li for genotyping transgenic mice. We also thank the University of Alabama Transgenic Facility. This work was supported by grants to P. W. from National Institute on Drug Abuse (DA10309, DA11742), National Institute of Mental Health (KO2 MH01152), National Institute on Aging (AG09219), and National Association for Research on Schizophrenia and Affective Disorders. ",
year = "1998",
month = oct,
doi = "10.1016/S0896-6273(00)80588-7",
language = "English",
volume = "21",
pages = "707--716",
journal = "Neuron",
issn = "0896-6273",
publisher = "Cell Press",
number = "4",
}