Homer binds a novel proline-rich motif and links group I metabotropic glutamate receptors with IP3 receptors

Jian Cheng Tu, Bo Xiao, Joseph P. Yuan, Anthony A. Lanahan, Kathleen Leoffert, Min Li, David J. Linden, Paul F. Worley

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Abstract

Group 1 metabotropic glutamate receptors (mGluRs) activate PI turnover and thereby trigger intracellular calcium release. Previously, we demonstrated that mGluRs form natural complexes with members of a family of Homer-related synaptic proteins. Here, we present evidence that Homer proteins form a physical tether linking mGluRs with the inositol trisphosphate receptors (IP3R). A novel proline-rich 'Homer ligand' (PPXXFr) is identified in group 1 mGluRs and IP3R, and these receptors coimmunoprecipitate as a complex with Homer from brain. Expression of the lEG form of Homer, which lacks the ability to cross-link, modulates mGluR- induced intracellular calcium release. These studies identify a novel mechanism in calcium signaling and provide evidence that an lEG, whose expression is driven by synaptic activity, can directly modify a specific synaptic function.

Original languageEnglish
Pages (from-to)717-726
Number of pages10
JournalNeuron
Volume21
Issue number4
DOIs
StatePublished - 1 Jan 1998

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Inositol 1,4,5-Trisphosphate Receptors
Metabotropic Glutamate Receptors
Proline
Calcium
Aptitude
Calcium Signaling
Inositol
Ligands
Brain
Proteins
metabotropic glutamate receptor type 1
Homer Scaffolding Proteins

Cite this

Tu, Jian Cheng ; Xiao, Bo ; Yuan, Joseph P. ; Lanahan, Anthony A. ; Leoffert, Kathleen ; Li, Min ; Linden, David J. ; Worley, Paul F. / Homer binds a novel proline-rich motif and links group I metabotropic glutamate receptors with IP3 receptors. In: Neuron. 1998 ; Vol. 21, No. 4. pp. 717-726.
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abstract = "Group 1 metabotropic glutamate receptors (mGluRs) activate PI turnover and thereby trigger intracellular calcium release. Previously, we demonstrated that mGluRs form natural complexes with members of a family of Homer-related synaptic proteins. Here, we present evidence that Homer proteins form a physical tether linking mGluRs with the inositol trisphosphate receptors (IP3R). A novel proline-rich 'Homer ligand' (PPXXFr) is identified in group 1 mGluRs and IP3R, and these receptors coimmunoprecipitate as a complex with Homer from brain. Expression of the lEG form of Homer, which lacks the ability to cross-link, modulates mGluR- induced intracellular calcium release. These studies identify a novel mechanism in calcium signaling and provide evidence that an lEG, whose expression is driven by synaptic activity, can directly modify a specific synaptic function.",
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Tu, JC, Xiao, B, Yuan, JP, Lanahan, AA, Leoffert, K, Li, M, Linden, DJ & Worley, PF 1998, 'Homer binds a novel proline-rich motif and links group I metabotropic glutamate receptors with IP3 receptors', Neuron, vol. 21, no. 4, pp. 717-726. https://doi.org/10.1016/S0896-6273(00)80589-9

Homer binds a novel proline-rich motif and links group I metabotropic glutamate receptors with IP3 receptors. / Tu, Jian Cheng; Xiao, Bo; Yuan, Joseph P.; Lanahan, Anthony A.; Leoffert, Kathleen; Li, Min; Linden, David J.; Worley, Paul F.

In: Neuron, Vol. 21, No. 4, 01.01.1998, p. 717-726.

Research output: Contribution to journalArticleResearchpeer-review

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