@article{34b479cf641444fc9094443f0dec4a2d,
title = "Homer binds a novel proline-rich motif and links group I metabotropic glutamate receptors with IP3 receptors",
abstract = "Group 1 metabotropic glutamate receptors (mGluRs) activate PI turnover and thereby trigger intracellular calcium release. Previously, we demonstrated that mGluRs form natural complexes with members of a family of Homer-related synaptic proteins. Here, we present evidence that Homer proteins form a physical tether linking mGluRs with the inositol trisphosphate receptors (IP3R). A novel proline-rich 'Homer ligand' (PPXXFr) is identified in group 1 mGluRs and IP3R, and these receptors coimmunoprecipitate as a complex with Homer from brain. Expression of the lEG form of Homer, which lacks the ability to cross-link, modulates mGluR- induced intracellular calcium release. These studies identify a novel mechanism in calcium signaling and provide evidence that an lEG, whose expression is driven by synaptic activity, can directly modify a specific synaptic function.",
author = "Tu, {Jian Cheng} and Bo Xiao and Yuan, {Joseph P.} and Lanahan, {Anthony A.} and Kathleen Leoffert and Min Li and Linden, {David J.} and Worley, {Paul F.}",
note = "Funding Information: We thank Maria Papapavlou and Dorit Gurfel for technical help, S. Ahn, X. Z. Qian, and A. Riccio for advice on gene gun protocols. We thank Alan Sharp and Christopher Ross of Johns Hopkins for IP3R Ab and full-length IP3R expression construct, respectively, and R. Urrutia of Mayo Clinic, Minnesota, for dynamin III cDNA. This work was supported by grants to P. W. from National Institute on Drug Abuse (DA 10309, DA 11742), National Institute of Mental Health (KO2 MH01152), National Institute on Aging (AG09219), and National Association for Research on Schizophrenia and Affective Disorders; to M. L. from National Institutes on Neurological Diseases and Stroke (NS 33324) and American Heart Association; and to D. L. from National Institute of Mental Health (MH 51106) and the Develbiss Fund.",
year = "1998",
month = oct,
doi = "10.1016/S0896-6273(00)80589-9",
language = "English",
volume = "21",
pages = "717--726",
journal = "Neuron",
issn = "0896-6273",
publisher = "Cell Press",
number = "4",
}