Abstract
Group 1 metabotropic glutamate receptors (mGluRs) activate PI turnover and thereby trigger intracellular calcium release. Previously, we demonstrated that mGluRs form natural complexes with members of a family of Homer-related synaptic proteins. Here, we present evidence that Homer proteins form a physical tether linking mGluRs with the inositol trisphosphate receptors (IP3R). A novel proline-rich 'Homer ligand' (PPXXFr) is identified in group 1 mGluRs and IP3R, and these receptors coimmunoprecipitate as a complex with Homer from brain. Expression of the lEG form of Homer, which lacks the ability to cross-link, modulates mGluR- induced intracellular calcium release. These studies identify a novel mechanism in calcium signaling and provide evidence that an lEG, whose expression is driven by synaptic activity, can directly modify a specific synaptic function.
| Original language | English |
|---|---|
| Pages (from-to) | 717-726 |
| Number of pages | 10 |
| Journal | Neuron |
| Volume | 21 |
| Issue number | 4 |
| DOIs | |
| State | Published - 1 Jan 1998 |
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Homer binds a novel proline-rich motif and links group I metabotropic glutamate receptors with IP3 receptors. / Tu, Jian Cheng; Xiao, Bo; Yuan, Joseph P.; Lanahan, Anthony A.; Leoffert, Kathleen; Li, Min; Linden, David J.; Worley, Paul F.
In: Neuron, Vol. 21, No. 4, 01.01.1998, p. 717-726.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Homer binds a novel proline-rich motif and links group I metabotropic glutamate receptors with IP3 receptors
AU - Tu, Jian Cheng
AU - Xiao, Bo
AU - Yuan, Joseph P.
AU - Lanahan, Anthony A.
AU - Leoffert, Kathleen
AU - Li, Min
AU - Linden, David J.
AU - Worley, Paul F.
PY - 1998/1/1
Y1 - 1998/1/1
N2 - Group 1 metabotropic glutamate receptors (mGluRs) activate PI turnover and thereby trigger intracellular calcium release. Previously, we demonstrated that mGluRs form natural complexes with members of a family of Homer-related synaptic proteins. Here, we present evidence that Homer proteins form a physical tether linking mGluRs with the inositol trisphosphate receptors (IP3R). A novel proline-rich 'Homer ligand' (PPXXFr) is identified in group 1 mGluRs and IP3R, and these receptors coimmunoprecipitate as a complex with Homer from brain. Expression of the lEG form of Homer, which lacks the ability to cross-link, modulates mGluR- induced intracellular calcium release. These studies identify a novel mechanism in calcium signaling and provide evidence that an lEG, whose expression is driven by synaptic activity, can directly modify a specific synaptic function.
AB - Group 1 metabotropic glutamate receptors (mGluRs) activate PI turnover and thereby trigger intracellular calcium release. Previously, we demonstrated that mGluRs form natural complexes with members of a family of Homer-related synaptic proteins. Here, we present evidence that Homer proteins form a physical tether linking mGluRs with the inositol trisphosphate receptors (IP3R). A novel proline-rich 'Homer ligand' (PPXXFr) is identified in group 1 mGluRs and IP3R, and these receptors coimmunoprecipitate as a complex with Homer from brain. Expression of the lEG form of Homer, which lacks the ability to cross-link, modulates mGluR- induced intracellular calcium release. These studies identify a novel mechanism in calcium signaling and provide evidence that an lEG, whose expression is driven by synaptic activity, can directly modify a specific synaptic function.
UR - http://www.scopus.com/inward/record.url?scp=0032192487&partnerID=8YFLogxK
U2 - 10.1016/S0896-6273(00)80589-9
DO - 10.1016/S0896-6273(00)80589-9
M3 - Article
VL - 21
SP - 717
EP - 726
JO - Neuron
JF - Neuron
SN - 0896-6273
IS - 4
ER -