HLA haplotypes and microsatellite polymorphisms in and around the major histocompatibility complex region in a Native American population with a high prevalence of scleroderma (systemic sclerosis)

Filemon K. Tan, D. N. Stivers, F. C. Arnett, R. Chakraborty, R. Howard, J. D. Reveille

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

Choctaw Native Americans in southeastern Oklahoma have the highest prevalence of scleroderma or systemic sclerosis yet found (469/100,000). An Amerindian HLA DR2 haplotype (DRB1*1602) was significantly associated with scleroderma in this population in a previous study. It is not known, however, if other disease genes are linked to this HLA haplotype. The regions flanking the HLA loci were studied with polymorphic microsatellite markers. An extended HLA DR2 (DRB1*1602, DQA1*0501, DQB1*0301, DPB1*1301) haplotype that includes the class I and III regions was identified which was significantly associated with scleroderma in the Oklahoma Choctaw. No other significant associations with microsatellite marker alleles immediately flanking the HLA region were found.

Original languageEnglish
Pages (from-to)74-80
Number of pages7
JournalTissue Antigens
Volume53
Issue number1
DOIs
StatePublished - 1999

Keywords

  • Major histocompatibility complex
  • Microsatellites
  • Native Americans
  • Systemic sclerosis
  • Topoisomerase I
  • Tumor necrosis factor

Fingerprint Dive into the research topics of 'HLA haplotypes and microsatellite polymorphisms in and around the major histocompatibility complex region in a Native American population with a high prevalence of scleroderma (systemic sclerosis)'. Together they form a unique fingerprint.

  • Cite this