HLA haplotypes and microsatellite polymorphisms in and around the major histocompatibility complex region in a Native American population with a high prevalence of scleroderma (systemic sclerosis)

Filemon K. Tan; D. N. Stivers; F. C. Arnett; R. Chakraborty; R. Howard; J. D. Reveille

doi:10.1034/j.1399-0039.1999.530108.x

HLA haplotypes and microsatellite polymorphisms in and around the major histocompatibility complex region in a Native American population with a high prevalence of scleroderma (systemic sclerosis)

Filemon K. Tan, D. N. Stivers, F. C. Arnett, R. Chakraborty, R. Howard, J. D. Reveille

School of Biomedical Sciences

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32 Scopus citations

Abstract

Choctaw Native Americans in southeastern Oklahoma have the highest prevalence of scleroderma or systemic sclerosis yet found (469/100,000). An Amerindian HLA DR2 haplotype (DRB1*1602) was significantly associated with scleroderma in this population in a previous study. It is not known, however, if other disease genes are linked to this HLA haplotype. The regions flanking the HLA loci were studied with polymorphic microsatellite markers. An extended HLA DR2 (DRB1*1602, DQA1*0501, DQB1*0301, DPB1*1301) haplotype that includes the class I and III regions was identified which was significantly associated with scleroderma in the Oklahoma Choctaw. No other significant associations with microsatellite marker alleles immediately flanking the HLA region were found.

Original language	English
Pages (from-to)	74-80
Number of pages	7
Journal	Tissue Antigens
Volume	53
Issue number	1
DOIs	https://doi.org/10.1034/j.1399-0039.1999.530108.x
State	Published - 1999

Keywords

Major histocompatibility complex
Microsatellites
Native Americans
Systemic sclerosis
Topoisomerase I
Tumor necrosis factor

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10.1034/j.1399-0039.1999.530108.x

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Tan, F. K., Stivers, D. N., Arnett, F. C., Chakraborty, R., Howard, R., & Reveille, J. D. (1999). HLA haplotypes and microsatellite polymorphisms in and around the major histocompatibility complex region in a Native American population with a high prevalence of scleroderma (systemic sclerosis). Tissue Antigens, 53(1), 74-80. https://doi.org/10.1034/j.1399-0039.1999.530108.x

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abstract = "Choctaw Native Americans in southeastern Oklahoma have the highest prevalence of scleroderma or systemic sclerosis yet found (469/100,000). An Amerindian HLA DR2 haplotype (DRB1*1602) was significantly associated with scleroderma in this population in a previous study. It is not known, however, if other disease genes are linked to this HLA haplotype. The regions flanking the HLA loci were studied with polymorphic microsatellite markers. An extended HLA DR2 (DRB1*1602, DQA1*0501, DQB1*0301, DPB1*1301) haplotype that includes the class I and III regions was identified which was significantly associated with scleroderma in the Oklahoma Choctaw. No other significant associations with microsatellite marker alleles immediately flanking the HLA region were found.",

keywords = "Major histocompatibility complex, Microsatellites, Native Americans, Systemic sclerosis, Topoisomerase I, Tumor necrosis factor",

author = "Tan, {Filemon K.} and Stivers, {D. N.} and Arnett, {F. C.} and R. Chakraborty and R. Howard and Reveille, {J. D.}",

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Tan, FK, Stivers, DN, Arnett, FC, Chakraborty, R, Howard, R & Reveille, JD 1999, 'HLA haplotypes and microsatellite polymorphisms in and around the major histocompatibility complex region in a Native American population with a high prevalence of scleroderma (systemic sclerosis)', Tissue Antigens, vol. 53, no. 1, pp. 74-80. https://doi.org/10.1034/j.1399-0039.1999.530108.x

HLA haplotypes and microsatellite polymorphisms in and around the major histocompatibility complex region in a Native American population with a high prevalence of scleroderma (systemic sclerosis). / Tan, Filemon K.; Stivers, D. N.; Arnett, F. C. et al.
In: Tissue Antigens, Vol. 53, No. 1, 1999, p. 74-80.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - HLA haplotypes and microsatellite polymorphisms in and around the major histocompatibility complex region in a Native American population with a high prevalence of scleroderma (systemic sclerosis)

AU - Tan, Filemon K.

AU - Stivers, D. N.

AU - Arnett, F. C.

AU - Chakraborty, R.

AU - Howard, R.

AU - Reveille, J. D.

PY - 1999

Y1 - 1999

N2 - Choctaw Native Americans in southeastern Oklahoma have the highest prevalence of scleroderma or systemic sclerosis yet found (469/100,000). An Amerindian HLA DR2 haplotype (DRB1*1602) was significantly associated with scleroderma in this population in a previous study. It is not known, however, if other disease genes are linked to this HLA haplotype. The regions flanking the HLA loci were studied with polymorphic microsatellite markers. An extended HLA DR2 (DRB1*1602, DQA1*0501, DQB1*0301, DPB1*1301) haplotype that includes the class I and III regions was identified which was significantly associated with scleroderma in the Oklahoma Choctaw. No other significant associations with microsatellite marker alleles immediately flanking the HLA region were found.

AB - Choctaw Native Americans in southeastern Oklahoma have the highest prevalence of scleroderma or systemic sclerosis yet found (469/100,000). An Amerindian HLA DR2 haplotype (DRB1*1602) was significantly associated with scleroderma in this population in a previous study. It is not known, however, if other disease genes are linked to this HLA haplotype. The regions flanking the HLA loci were studied with polymorphic microsatellite markers. An extended HLA DR2 (DRB1*1602, DQA1*0501, DQB1*0301, DPB1*1301) haplotype that includes the class I and III regions was identified which was significantly associated with scleroderma in the Oklahoma Choctaw. No other significant associations with microsatellite marker alleles immediately flanking the HLA region were found.

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KW - Microsatellites

KW - Native Americans

KW - Systemic sclerosis

KW - Topoisomerase I

KW - Tumor necrosis factor

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HLA haplotypes and microsatellite polymorphisms in and around the major histocompatibility complex region in a Native American population with a high prevalence of scleroderma (systemic sclerosis)

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Keywords

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