HLA-DQA1 subtyping data in the Swiss population

Christian Gehrig, Manfred N. Hochmeister, Bruce Budowle, Rebecca Reynolds, Richard Dirnhofer

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Allele- and genotype frequencies for the polymerase chain reaction-based DNA genetic marker HLA-DQA1 were determined previously in a Swiss sample population (n = 200). In this study we subtyped the allele 4 in the same Swiss Caucasian population sample (distinguishing the 4.1 allele from the 4.2 and 4.3 alleles) using the AmpliType® PM+ DQA1 PCR Amplification and Typing Kit. No deviations from Hardy-Weinberg equilibrium could be observed. The power of discrimination (Pd) of the HLA-DQA1 locus without subtyping the 4 allele for Swiss Caucasians was 0.931, when subtyping the 4 allele the value is 0.938. The frequency data can be used in forensic analyses to estimate the frequency of a HLA-DQA1 profile in the Swiss population.

Original languageEnglish
Pages (from-to)27-30
Number of pages4
JournalForensic Science International
Volume83
Issue number1
DOIs
StatePublished - 11 Nov 1996

Keywords

  • Hardy-Weinberg expectations
  • HLA-DQA1
  • PCR
  • Population databases
  • Subtypes
  • Swiss

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