Abstract
Allele- and genotype frequencies for the polymerase chain reaction-based DNA genetic marker HLA-DQA1 were determined previously in a Swiss sample population (n = 200). In this study we subtyped the allele 4 in the same Swiss Caucasian population sample (distinguishing the 4.1 allele from the 4.2 and 4.3 alleles) using the AmpliType® PM+ DQA1 PCR Amplification and Typing Kit. No deviations from Hardy-Weinberg equilibrium could be observed. The power of discrimination (Pd) of the HLA-DQA1 locus without subtyping the 4 allele for Swiss Caucasians was 0.931, when subtyping the 4 allele the value is 0.938. The frequency data can be used in forensic analyses to estimate the frequency of a HLA-DQA1 profile in the Swiss population.
Original language | English |
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Pages (from-to) | 27-30 |
Number of pages | 4 |
Journal | Forensic Science International |
Volume | 83 |
Issue number | 1 |
DOIs | |
State | Published - 11 Nov 1996 |
Keywords
- HLA-DQA1
- Hardy-Weinberg expectations
- PCR
- Population databases
- Subtypes
- Swiss