HIV antiretroviral drug combination induces endothelial mitochondrial dysfunction and reactive oxygen species production, but not apoptosis

Keyphrases

• 4′,6-diamidino-2-phenylindole 10%
• 8-isoprostane 10%
• Activity Assay 10%
• Annexin V 10%
• Antioxidant 10%
• Antiretroviral Therapy 100%
• Antiviral Drugs 100%
• Apoptosis 100%
• Atherogenesis 10%
• Biotin 10%
• Cardiovascular Disease 10%
• Caspase-3 Activity 10%
• Catalase 40%
• Cell Permeable 10%
• Combination of Therapies 10%
• Combination Therapy 10%
• Combination Treatment 20%
• Drug Combination 100%
• End-labelling 10%
• Endothelial Cell Apoptosis 10%
• Endothelial Cells 10%
• Endothelial Dysfunction 40%
• Fluorescent Indicator 10%
• HIV Antiretrovirals 100%
• HIV Patients 10%
• HIV-associated 10%
• Human Umbilical Vein Endothelial Cells (HUVECs) 20%
• In Vivo Applications 10%
• Indinavir 30%
• Induced Apoptosis 10%
• Initiating Event 10%
• Long-term Antiretroviral Therapy 10%
• Major Components 10%
• Metalloporphyrin 10%
• Microscopy 10%
• Mitochondria 10%
• Mitochondrial Damage 10%
• Mitochondrial Dysfunction 100%
• Mitochondrial Function 10%
• Mitochondrial Localization 10%
• Mitochondrial Reactive Oxygen Species (mtROS) 20%
• Mitochondrial Targeting 20%
• MnTBAP 10%
• Nucleoside Reverse Transcriptase Inhibitors 10%
• PGF2 20%
• Protease Inhibitors 10%
• Reactive Oxygen Species 60%
• Reactive Oxygen Species Production 100%
• Rodents 10%
• Terminal Deoxynucleotidyl Transferase 10%
• Toxicity Mechanism 10%
• Treatment Group 10%

Neuroscience

• 8 Isoprostane 8%
• [5,10,15,20 Tetrakis(4 Carboxyphenyl) 21h,23h Porphine]manganese(iii) Chloride 8%
• Antioxidant 8%
• Antiretroviral Drugs 100%
• Biotin 8%
• Caspase 3 8%
• Catalase 33%
• Combination Drug 100%
• DNA Nucleotidylexotransferase 8%
• Human Immunodeficiency Virus 100%
• Human Umbilical Vein Endothelial Cell 16%
• In Vitro 8%
• Indinavir 25%
• Lipocortin 5 8%
• Metalloporphyrin 8%
• Mitochondrial Function 8%
• Mitochondrion 41%
• Proteinase 8%
• Reactive Oxygen Species 100%
• Reverse-Transcriptase Inhibitor 8%
• Staining Technique 8%
• TUNEL Assay 8%

Pharmacology, Toxicology and Pharmaceutical Science

• 8 Isoprostane 8%
• [5,10,15,20 Tetrakis(4 Carboxyphenyl) 21h,23h Porphine]manganese(iii) Chloride 8%
• Antioxidant 8%
• Atherogenesis 8%
• Atherosclerosis 8%
• Biotin 8%
• Cardiovascular Disease 8%
• Caspase 3 8%
• Catalase 33%
• Combination Drug 100%
• Combination Therapy 8%
• DNA Nucleotidylexotransferase 8%
• Endothelial Dysfunction 33%
• HIV 100%
• Indinavir 25%
• Injury 8%
• Lipocortin 5 8%
• Metalloporphyrin 8%
• Proteinase Inhibitor 8%
• Reactive Oxygen Metabolite 100%
• RNA Directed DNA Polymerase Inhibitor 8%