HIV-1 tat promotes lysosomal exocytosis in astrocytes and contributes to astrocyte-mediated tat neurotoxicity

Keyphrases

• Astrocytes 100%
• HIV-1 Tat 100%
• Neurotoxicity 100%
• Lysosomal Exocytosis 100%
• Acidic Proteins 36%
• Endoplasmic Reticulum Stress (ER stress) 27%
• Protein Expression 18%
• Supernatant 18%
• Molecular Mechanism 9%
• Protein Activation 9%
• Neurodegenerative Diseases 9%
• Plasma Membrane 9%
• NeuroAIDS 9%
• TAT Peptide 9%
• Membrane Protein 9%
• Astrocytosis 9%
• Mass Spectrometry 9%
• Protein Upregulation 9%
• Protein Aggregation 9%
• Unfolded Protein Response 9%
• Human Astrocytes 9%
• Stress Induction 9%
• Two-dimensional Gel Electrophoresis 9%
• Pseudotype 9%
• Tightly Coupled 9%
• Mouse Astrocytes 9%
• Enzyme Membrane 9%
• Hydrolytic Enzymes 9%

Neuroscience

• Astrocyte 100%
• Human Immunodeficiency Virus 100%
• Neurotoxicity 100%
• Exocytosis 100%
• Acid Protein 30%
• Endoplasmic Reticulum Stress 23%
• Protein Expression 15%
• Neurodegenerative Disorder 7%
• Cell Membrane 7%
• Herpes Simplex Virus Protein Vmw65 7%
• Mass Spectrometry 7%
• Protein Aggregation 7%
• Unfolded Protein Response 7%
• Hydrolase 7%
• Two Dimensional Polyacrylamide Gel Electrophoresis 7%

Pharmacology, Toxicology and Pharmaceutical Science

• HIV 100%
• Neurotoxicity 100%
• Acid Protein 57%
• Degenerative Disease 14%
• Transactivator Protein 14%
• Astrocytosis 14%
• Infection 14%
• Membrane Protein 14%
• Hydrolase 14%
• Two Dimensional Polyacrylamide Gel Electrophoresis 14%