HIV-1 tat alters neuronal autophagy by modulating autophagosome fusion to the lysosome: Implications for HIV-associated neurocognitive disorders

Keyphrases

• HIV-1 Tat 100%
• HIV-associated Neurocognitive Disorders 100%
• Neuronal Autophagy 100%
• Autophagosome 100%
• Lysosome 100%
• Autophagy 85%
• LC3-II 42%
• LAMP2 42%
• Aging 28%
• Neurodegeneration 28%
• Dysregulated 28%
• SQSTM1 28%
• Knockdown 14%
• Overexpression 14%
• Co-treatment 14%
• Antiretroviral Therapy 14%
• Colocalization 14%
• Dose Effect 14%
• TAT Peptide 14%
• HIV Patients 14%
• Neurotoxicity 14%
• Viral Glycoprotein 14%
• HIV Infection 14%
• Co-immunoprecipitation (co-IP) 14%
• Tg Mouse 14%
• Aging Patients 14%
• Microtubule-associated Protein 14%
• Monocyte-derived Cells 14%
• Light Chain 14%
• Rapamycin Treatment 14%
• Beclin-1 14%
• Enriched Fractions 14%
• LC3 Puncta 14%
• 3-methyladenine (3-MA) 14%
• Autophagosome-lysosome Fusion 14%
• HIV+ 14%
• Autophagosome Accumulation 14%
• Autophagic Degradation 14%
• Bafilomycin A1 14%
• Intracellular Components 14%

Biochemistry, Genetics and Molecular Biology

• Human Immunodeficiency Virus 100%
• Autophagy 100%
• Human Immunodeficiency Virus 1 100%
• Lysosome 100%
• Autophagosome 100%
• Membrane Protein 33%
• Sequestosome 1 22%
• Tat (HIV) 11%
• Herpes Simplex Virus Protein Vmw65 11%
• Lifespan 11%
• Synapsin I 11%
• In Vivo Study 11%
• Light Chain 11%
• Bafilomycin 11%
• Microtubule-Associated Protein 11%

Neuroscience

• Human Immunodeficiency Virus 100%
• Autophagy 100%
• HIV Associated Dementia 100%
• Lysosome 100%
• In Vivo 22%
• In Vitro 22%
• Neurodegeneration 22%
• Sequestosome 1 22%
• Herpes Simplex Virus Protein Vmw65 11%
• Neurotoxicity 11%
• Beclin 1 11%
• Light Chain 11%
• Bafilomycin 11%
• 3 Methyladenine 11%
• Microtubule Associated Protein 1 11%
• Sirolimus 11%