HIV-1-Mediated Acceleration of Oncovirus-Related Non-AIDS-Defining Cancers

Jessica Proulx, Maria Ghaly, In Woo Park, Kathleen Borgmann

Research output: Contribution to journalReview articlepeer-review

Abstract

With the advent of combination antiretroviral therapy (cART), overall survival has been im-proved, and the incidence of acquired immunodeficiency syndrome (AIDS)-defining cancers has also been remarkably reduced. However, non-AIDS-defining cancers among human immunodeficiency virus-1 (HIV-1)-associated malignancies have increased significantly so that cancer is the leading cause of death in people living with HIV in certain highly developed countries, such as France. How-ever, it is currently unknown how HIV-1 infection raises oncogenic virus-mediated cancer risks in the HIV-1 and oncogenic virus co-infected patients, and thus elucidation of the molecular mechanisms for how HIV-1 expedites the oncogenic viruses-triggered tumorigenesis in the co-infected hosts is imperative for developing therapeutics to cure or impede the carcinogenesis. Hence, this review is focused on HIV-1 and oncogenic virus co-infection-mediated molecular processes in the acceleration of non-AIDS-defining cancers.

Original languageEnglish
Article number768
JournalBiomedicines
Volume10
Issue number4
DOIs
StatePublished - Apr 2022

Keywords

  • HBV
  • HCV
  • HPV
  • hepatitis
  • human immunodeficiency virus
  • human papillomavirus

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