Abstract
With the advent of combination antiretroviral therapy (cART), overall survival has been im-proved, and the incidence of acquired immunodeficiency syndrome (AIDS)-defining cancers has also been remarkably reduced. However, non-AIDS-defining cancers among human immunodeficiency virus-1 (HIV-1)-associated malignancies have increased significantly so that cancer is the leading cause of death in people living with HIV in certain highly developed countries, such as France. How-ever, it is currently unknown how HIV-1 infection raises oncogenic virus-mediated cancer risks in the HIV-1 and oncogenic virus co-infected patients, and thus elucidation of the molecular mechanisms for how HIV-1 expedites the oncogenic viruses-triggered tumorigenesis in the co-infected hosts is imperative for developing therapeutics to cure or impede the carcinogenesis. Hence, this review is focused on HIV-1 and oncogenic virus co-infection-mediated molecular processes in the acceleration of non-AIDS-defining cancers.
Original language | English |
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Article number | 768 |
Journal | Biomedicines |
Volume | 10 |
Issue number | 4 |
DOIs | |
State | Published - Apr 2022 |
Keywords
- HBV
- HCV
- HPV
- hepatitis
- human immunodeficiency virus
- human papillomavirus