@article{87def8850d594cf19826d0d72fab4eaf,
title = "Highly Selective Dopamine D3 Receptor Antagonists with Arylated Diazaspiro Alkane Cores",
abstract = "A series of potent and selective D3 receptor (D3R) analogues with diazaspiro alkane cores were synthesized. Radioligand binding of compounds 11, 14, 15a, and 15c revealed favorable D3R affinity (Ki = 12-25.6 nM) and were highly selective for D3R vs D3R (ranging from 264- to 905-fold). Variation of these novel ligand architectures can be achieved using our previously reported 10-20 min benchtop C-N cross-coupling methodology, affording a broad range of arylated diazaspiro precursors.",
author = "Reilly, {Sean W.} and Suzy Griffin and Michelle Taylor and Kristoffer Sahlholm and Weng, {Chi Chang} and Kuiying Xu and Jacome, {Daniel A.} and Luedtke, {Robert R.} and Mach, {Robert H.}",
note = "Funding Information: National Institute on Drug Abuse (Grant R01 DA29840-07 to R.H.M., Grant R01 DA23957-06 to R.R.L.) is gratefully acknowledged for financial support. S.W.R. is supported by Training Grant 5T32DA028874-07. Publisher Copyright: {\textcopyright} 2017 American Chemical Society.",
year = "2017",
month = dec,
day = "14",
doi = "10.1021/acs.jmedchem.7b01248",
language = "English",
volume = "60",
pages = "9905--9910",
journal = "Journal of Medicinal Chemistry",
issn = "0022-2623",
publisher = "American Chemical Society",
number = "23",
}