@article{946609095877481c9e9273f5683fb2e6,
title = "High Salt Intake Increases Blood Pressure via BDNF-Mediated Downregulation of KCC2 and Impaired Baroreflex Inhibition of Vasopressin Neurons",
abstract = "The mechanisms by which dietary salt promotes hypertension are unknown. Previous work established that plasma [Na+] and osmolality rise in proportion with salt intake and thus promote release of vasopressin (VP) from the neurohypophysis. Although high levels of circulating VP can increase blood pressure, this effect is normally prevented by a potent GABAergic inhibition of VP neurons by aortic baroreceptors. Here we show that chronic high salt intake impairs baroreceptor inhibition of rat VP neurons through a brain-derived neurotrophic factor (BDNF)-dependent activation of TrkB receptors and downregulation of KCC2 expression, which prevents inhibitory GABAergic signaling. We show that high salt intake increases the spontaneous firing rate of VP neurons invivo and that circulating VP contributes significantly to the elevation of arterial pressure under these conditions. These results provide the first demonstration that dietary salt can affect blood pressure through neurotrophin-induced plasticity in a central homeostatic circuit.",
author = "Choe, {Katrina Y.} and Han, {Su Y.} and Perrine Gaub and Brent Shell and Voisin, {Daniel L.} and Knapp, {Blayne A.} and Barker, {Philip A.} and Brown, {Colin H.} and Cunningham, {J. Thomas} and Bourque, {Charles W.}",
note = "Funding Information: This work was supported by grants from the Canadian Institutes of Health Research to C.W.B. (MOP-9939) and P.A.B. (FRN37850), by National Institutes of Health grants to J.T.C. (R56 HL062579 and R01 HL119458), by a Cong{\'e} pour recherche ou conversion th{\'e}matique from Universit{\'e} de Bordeaux to D.L.V., by a James McGill Research Chair to C.W.B., and by a University of Otago Postgraduate Scholarship to S.Y.H. The Research Institute of the McGill University Health Center receives financial support from the Fonds de Recherche Sant{\'e} Qu{\'e}bec. We also thank Dr. R. James Turner (NIH) for supplying NKCC1 antibody, Dr. Hal Gainer (NIH) for supplying anti-VP-neurophysin antibody, and Dr. Eric Trudel, Xinying Niu, and Joel T. Little for technical assistance. Publisher Copyright: {\textcopyright} 2015 Elsevier Inc.",
year = "2015",
month = feb,
day = "4",
doi = "10.1016/j.neuron.2014.12.048",
language = "English",
volume = "85",
pages = "549--560",
journal = "Neuron",
issn = "0896-6273",
publisher = "Cell Press",
number = "3",
}