High-frequency phenotypic switching in Candida albicans

David R. Soll, Brian Morrow, Thyagarajan Srikantha

Research output: Contribution to journalArticlepeer-review

92 Scopus citations


Most strains of Candida albicans are capable of switching spontaneously and at high frequencies between a number of phenotypes distinguished by colony morphology. Unlike switching in many other microbial pathogens, switching in C. albicans is pleiotropic, affecting several morphological and physiological parameters. Recently, the first phase-specific genes were identified and shown to be regulated at the level of gene transcription.

Original languageEnglish
Pages (from-to)61-65
Number of pages5
JournalTrends in Genetics
Issue number2
StatePublished - Feb 1993


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