High-frequency phenotypic switching in Candida albicans

David R. Soll; Brian Morrow; Thyagarajan Srikantha

doi:10.1016/0168-9525(93)90189-O

High-frequency phenotypic switching in Candida albicans

David R. Soll, Brian Morrow, Thyagarajan Srikantha

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92 Scopus citations

Abstract

Most strains of Candida albicans are capable of switching spontaneously and at high frequencies between a number of phenotypes distinguished by colony morphology. Unlike switching in many other microbial pathogens, switching in C. albicans is pleiotropic, affecting several morphological and physiological parameters. Recently, the first phase-specific genes were identified and shown to be regulated at the level of gene transcription.

Original language	English
Pages (from-to)	61-65
Number of pages	5
Journal	Trends in Genetics
Volume	9
Issue number	2
DOIs	https://doi.org/10.1016/0168-9525(93)90189-O
State	Published - Feb 1993

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title = "High-frequency phenotypic switching in Candida albicans",

abstract = "Most strains of Candida albicans are capable of switching spontaneously and at high frequencies between a number of phenotypes distinguished by colony morphology. Unlike switching in many other microbial pathogens, switching in C. albicans is pleiotropic, affecting several morphological and physiological parameters. Recently, the first phase-specific genes were identified and shown to be regulated at the level of gene transcription.",

author = "Soll, {David R.} and Brian Morrow and Thyagarajan Srikantha",

note = "Funding Information: We thank M. Bergen and J. Anderson for their help in our research. Work in our laboratory was supported by PHS grant No. AI23922 from NIH.",

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AU - Morrow, Brian

AU - Srikantha, Thyagarajan

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PY - 1993/2

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N2 - Most strains of Candida albicans are capable of switching spontaneously and at high frequencies between a number of phenotypes distinguished by colony morphology. Unlike switching in many other microbial pathogens, switching in C. albicans is pleiotropic, affecting several morphological and physiological parameters. Recently, the first phase-specific genes were identified and shown to be regulated at the level of gene transcription.

AB - Most strains of Candida albicans are capable of switching spontaneously and at high frequencies between a number of phenotypes distinguished by colony morphology. Unlike switching in many other microbial pathogens, switching in C. albicans is pleiotropic, affecting several morphological and physiological parameters. Recently, the first phase-specific genes were identified and shown to be regulated at the level of gene transcription.

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High-frequency phenotypic switching in Candida albicans

Abstract

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