High burden of malaria following scale-up of control interventions in Nchelenge District, Luapula Province, Zambia

Victor M. Mukonka, Emmanuel Chanda, Ubydul Haque, Mulakwa Kamuliwo, Gabriel Mushinge, Jackson Chileshe, Kennedy A. Chibwe, Douglas E. Norris, Modest Mulenga, Mike Chaponda, Mbanga Muleba, Gregory E. Glass, William J. Moss

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Abstract

Background: Malaria control interventions have been scaled-up in Zambia in conjunction with a malaria surveillance system. Although substantial progress has been achieved in reducing morbidity and mortality, national and local information demonstrated marked heterogeneity in the impact of malaria control across the country. This study reports the high burden of malaria in Nchelenge District, Luapula Province, Zambia from 2006 to 2012 after seven years of control measures. Methods. Yearly aggregated information on cases of malaria, malaria deaths, use of malaria diagnostics, and malaria control interventions from 2006 to 2012 were obtained from the Nchelenge District Health Office. Trends in the number of malaria cases, methods of diagnosis, malaria positivity rate among pregnant women, and intervention coverage were analysed using descriptive statistics. Results: Malaria prevalence remained high, increasing from 38% in 2006 to 53% in 2012. Increasing numbers of cases of severe malaria were reported until 2010. Intense seasonal malaria transmission was observed with seasonal declines in the number of cases between April and August, although malaria transmission continued throughout the year. Clinical diagnosis without accompanying confirmation declined from 95% in 2006 to 35% in 2012. Intervention coverage with long-lasting insecticide-treated nets and indoor residual spraying increased from 2006 to 2012. Conclusions: Despite high coverage with vector control interventions, the burden of malaria in Nchelenge District, Zambia remained high. The high parasite prevalence could accurately reflect the true burden, perhaps in part as a consequence of population movement, or improved access to care and case reporting. Quality information at fine spatial scales will be critical for targeting effective interventions and measurement of progress.

Original languageEnglish
Article number153
JournalMalaria Journal
Volume13
Issue number1
DOIs
StatePublished - 23 Apr 2014

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Zambia
Malaria
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Mukonka, Victor M. ; Chanda, Emmanuel ; Haque, Ubydul ; Kamuliwo, Mulakwa ; Mushinge, Gabriel ; Chileshe, Jackson ; Chibwe, Kennedy A. ; Norris, Douglas E. ; Mulenga, Modest ; Chaponda, Mike ; Muleba, Mbanga ; Glass, Gregory E. ; Moss, William J. / High burden of malaria following scale-up of control interventions in Nchelenge District, Luapula Province, Zambia. In: Malaria Journal. 2014 ; Vol. 13, No. 1.
@article{4b8b4c93c2ed4db78d619779630d8c1d,
title = "High burden of malaria following scale-up of control interventions in Nchelenge District, Luapula Province, Zambia",
abstract = "Background: Malaria control interventions have been scaled-up in Zambia in conjunction with a malaria surveillance system. Although substantial progress has been achieved in reducing morbidity and mortality, national and local information demonstrated marked heterogeneity in the impact of malaria control across the country. This study reports the high burden of malaria in Nchelenge District, Luapula Province, Zambia from 2006 to 2012 after seven years of control measures. Methods. Yearly aggregated information on cases of malaria, malaria deaths, use of malaria diagnostics, and malaria control interventions from 2006 to 2012 were obtained from the Nchelenge District Health Office. Trends in the number of malaria cases, methods of diagnosis, malaria positivity rate among pregnant women, and intervention coverage were analysed using descriptive statistics. Results: Malaria prevalence remained high, increasing from 38{\%} in 2006 to 53{\%} in 2012. Increasing numbers of cases of severe malaria were reported until 2010. Intense seasonal malaria transmission was observed with seasonal declines in the number of cases between April and August, although malaria transmission continued throughout the year. Clinical diagnosis without accompanying confirmation declined from 95{\%} in 2006 to 35{\%} in 2012. Intervention coverage with long-lasting insecticide-treated nets and indoor residual spraying increased from 2006 to 2012. Conclusions: Despite high coverage with vector control interventions, the burden of malaria in Nchelenge District, Zambia remained high. The high parasite prevalence could accurately reflect the true burden, perhaps in part as a consequence of population movement, or improved access to care and case reporting. Quality information at fine spatial scales will be critical for targeting effective interventions and measurement of progress.",
author = "Mukonka, {Victor M.} and Emmanuel Chanda and Ubydul Haque and Mulakwa Kamuliwo and Gabriel Mushinge and Jackson Chileshe and Chibwe, {Kennedy A.} and Norris, {Douglas E.} and Modest Mulenga and Mike Chaponda and Mbanga Muleba and Glass, {Gregory E.} and Moss, {William J.}",
year = "2014",
month = "4",
day = "23",
doi = "10.1186/1475-2875-13-153",
language = "English",
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Mukonka, VM, Chanda, E, Haque, U, Kamuliwo, M, Mushinge, G, Chileshe, J, Chibwe, KA, Norris, DE, Mulenga, M, Chaponda, M, Muleba, M, Glass, GE & Moss, WJ 2014, 'High burden of malaria following scale-up of control interventions in Nchelenge District, Luapula Province, Zambia', Malaria Journal, vol. 13, no. 1, 153. https://doi.org/10.1186/1475-2875-13-153

High burden of malaria following scale-up of control interventions in Nchelenge District, Luapula Province, Zambia. / Mukonka, Victor M.; Chanda, Emmanuel; Haque, Ubydul; Kamuliwo, Mulakwa; Mushinge, Gabriel; Chileshe, Jackson; Chibwe, Kennedy A.; Norris, Douglas E.; Mulenga, Modest; Chaponda, Mike; Muleba, Mbanga; Glass, Gregory E.; Moss, William J.

In: Malaria Journal, Vol. 13, No. 1, 153, 23.04.2014.

Research output: Contribution to journalArticle

TY - JOUR

T1 - High burden of malaria following scale-up of control interventions in Nchelenge District, Luapula Province, Zambia

AU - Mukonka, Victor M.

AU - Chanda, Emmanuel

AU - Haque, Ubydul

AU - Kamuliwo, Mulakwa

AU - Mushinge, Gabriel

AU - Chileshe, Jackson

AU - Chibwe, Kennedy A.

AU - Norris, Douglas E.

AU - Mulenga, Modest

AU - Chaponda, Mike

AU - Muleba, Mbanga

AU - Glass, Gregory E.

AU - Moss, William J.

PY - 2014/4/23

Y1 - 2014/4/23

N2 - Background: Malaria control interventions have been scaled-up in Zambia in conjunction with a malaria surveillance system. Although substantial progress has been achieved in reducing morbidity and mortality, national and local information demonstrated marked heterogeneity in the impact of malaria control across the country. This study reports the high burden of malaria in Nchelenge District, Luapula Province, Zambia from 2006 to 2012 after seven years of control measures. Methods. Yearly aggregated information on cases of malaria, malaria deaths, use of malaria diagnostics, and malaria control interventions from 2006 to 2012 were obtained from the Nchelenge District Health Office. Trends in the number of malaria cases, methods of diagnosis, malaria positivity rate among pregnant women, and intervention coverage were analysed using descriptive statistics. Results: Malaria prevalence remained high, increasing from 38% in 2006 to 53% in 2012. Increasing numbers of cases of severe malaria were reported until 2010. Intense seasonal malaria transmission was observed with seasonal declines in the number of cases between April and August, although malaria transmission continued throughout the year. Clinical diagnosis without accompanying confirmation declined from 95% in 2006 to 35% in 2012. Intervention coverage with long-lasting insecticide-treated nets and indoor residual spraying increased from 2006 to 2012. Conclusions: Despite high coverage with vector control interventions, the burden of malaria in Nchelenge District, Zambia remained high. The high parasite prevalence could accurately reflect the true burden, perhaps in part as a consequence of population movement, or improved access to care and case reporting. Quality information at fine spatial scales will be critical for targeting effective interventions and measurement of progress.

AB - Background: Malaria control interventions have been scaled-up in Zambia in conjunction with a malaria surveillance system. Although substantial progress has been achieved in reducing morbidity and mortality, national and local information demonstrated marked heterogeneity in the impact of malaria control across the country. This study reports the high burden of malaria in Nchelenge District, Luapula Province, Zambia from 2006 to 2012 after seven years of control measures. Methods. Yearly aggregated information on cases of malaria, malaria deaths, use of malaria diagnostics, and malaria control interventions from 2006 to 2012 were obtained from the Nchelenge District Health Office. Trends in the number of malaria cases, methods of diagnosis, malaria positivity rate among pregnant women, and intervention coverage were analysed using descriptive statistics. Results: Malaria prevalence remained high, increasing from 38% in 2006 to 53% in 2012. Increasing numbers of cases of severe malaria were reported until 2010. Intense seasonal malaria transmission was observed with seasonal declines in the number of cases between April and August, although malaria transmission continued throughout the year. Clinical diagnosis without accompanying confirmation declined from 95% in 2006 to 35% in 2012. Intervention coverage with long-lasting insecticide-treated nets and indoor residual spraying increased from 2006 to 2012. Conclusions: Despite high coverage with vector control interventions, the burden of malaria in Nchelenge District, Zambia remained high. The high parasite prevalence could accurately reflect the true burden, perhaps in part as a consequence of population movement, or improved access to care and case reporting. Quality information at fine spatial scales will be critical for targeting effective interventions and measurement of progress.

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