TY - JOUR
T1 - Heredity, stress and blood pressure, a family set method-V. Heritability estimates
AU - Chakraborty, Ranajit
AU - Schull, William J.
AU - Harburg, Ernest
AU - Schork, M. Anthony
AU - Roeper, Peter
N1 - Funding Information:
*We gratefully acknowledge the support of the National Institutes of Health through grant GM 19513. Also funded by National Center for Chronic Disease Control, No. CD-00209-01, 02, 03; National Center for Health Services, Research and Development, No. HS 00164-04; National Association of Mental Health; Michigan Heart Association; National Heart and Lung Institute, No. HE 13329-01, 02, 03; American Heart Association; National Institute of Mental Health, No. MH 20621-01; Fannie E. Rippel Foundation. tDirector, Center for Demographic and Population Genetics, The University of Texas, Houston. IResearch Scientist, Department of Epidemiology, School of Public Health, and Department of Psy-chology, The University of Michigan. $Professor, Department of Biostatistics, School of Public Health, The University of Michigan. TRescarch Associate, Program for Urban Health Research, The University of Michigan. 683
PY - 1977/10
Y1 - 1977/10
N2 - This fifth article in the series, reports on a general method for estimating heritabilities based upon family sets, illustrated for a particular family grouping, namely, one which consists of an index person, his or her sibling, first cousin, and a randomly selected unrelated individual. This method is applied to the estimation of the heritabilities of systolic and diastolic blood pressure in the presence of extraneous concomitant variation as well as classificatory variables of interest. Analysis fails to disclose significant racial differences in the heritability of these two pressures, and indeed, suggests that in both blacks and whites, nongenetic variables contribute more to the variation in blood pressure which is observed than do genetic differences between individuals. It is argued that the difference between these findings and those associated with some prior investigations is attributable to ascribing effects to genetic causation, which in fact were due to shared environments or temporal trends.
AB - This fifth article in the series, reports on a general method for estimating heritabilities based upon family sets, illustrated for a particular family grouping, namely, one which consists of an index person, his or her sibling, first cousin, and a randomly selected unrelated individual. This method is applied to the estimation of the heritabilities of systolic and diastolic blood pressure in the presence of extraneous concomitant variation as well as classificatory variables of interest. Analysis fails to disclose significant racial differences in the heritability of these two pressures, and indeed, suggests that in both blacks and whites, nongenetic variables contribute more to the variation in blood pressure which is observed than do genetic differences between individuals. It is argued that the difference between these findings and those associated with some prior investigations is attributable to ascribing effects to genetic causation, which in fact were due to shared environments or temporal trends.
UR - http://www.scopus.com/inward/record.url?scp=0017603719&partnerID=8YFLogxK
U2 - 10.1016/0021-9681(77)90025-X
DO - 10.1016/0021-9681(77)90025-X
M3 - Article
C2 - 925123
AN - SCOPUS:0017603719
SN - 0021-9681
VL - 30
SP - 683
EP - 699
JO - Journal of Chronic Diseases
JF - Journal of Chronic Diseases
IS - 10
ER -