Haloperidol and reduced haloperidol plasma levels in Chinese vs. non-Chinese psychiatric patients

Michael W. Jann, Wen Ho Chang, Chester M. Davis, Teng Yi Chen, Hwei Chuang Deng, For Wei Lung, Larry Ereshefsky, Stephen R. Saklad, Ann L. Richards

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Abstract

Haloperidol and reduced haloperidol plasma concentrations were measured in age-matched Chinese and non-Chinese patients (n = 32). Steady-state plasma concentrations were obtained 10-12 hours after the bedtime dose. Haloperidol and reduced haloperidol concentrations were measured by liquid chromatography and radioimmunoassay. Haloperidol plasma concentrations did not significantly differ between the populations, but reduced haloperidol levels were 3 times greater in non-Chinese patients than in Chinese patients. The incidence of extrapyramidal side effects was higher in Chinese patients (18 vs. 10), while non-Chinese patients with extrapyramidal symptoms had higher reduced haloperidol plasma levels. Logistic regression analysis revealed that ethnicity and reduced haloperidol/haloperidol ratios were important variables in predicting extrapyramidal symptoms. These results suggest that the metabolism and disposition of haloperidol and reduced haloperidol could differ among ethnic populations.

Original languageEnglish
Pages (from-to)45-52
Number of pages8
JournalPsychiatry Research
Volume30
Issue number1
DOIs
StatePublished - Oct 1989

Keywords

  • Chinese
  • Haloperidol
  • plasma levels
  • reduced haloperidol
  • schizophrenia

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    Jann, M. W., Chang, W. H., Davis, C. M., Chen, T. Y., Deng, H. C., Lung, F. W., Ereshefsky, L., Saklad, S. R., & Richards, A. L. (1989). Haloperidol and reduced haloperidol plasma levels in Chinese vs. non-Chinese psychiatric patients. Psychiatry Research, 30(1), 45-52. https://doi.org/10.1016/0165-1781(89)90170-4