Haloperidol and reduced haloperidol plasma concentrations after a loading dose regimen with haloperidol decanoate

Michael W. Jann, Fu Chuan Wei, Hsin Nan Lin, Ching Piao-Chien, Wen Ho Chang

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Haloperidol and reduced haloperidol plasma levels were measured in schizophrenic patients who received both oral (10 mg, N = 16 and 20 mg, N = 4) and depot haloperidol treatment. Patients were of Asian ethnicity and were safely and effectively converted from oral to depot therapy using a loading dose regimen using a 100 mg weekly injection interval for 4 weeks, biweekly for one month and then monthly. Significant correlations were found for plasma haloperidol and reduced haloperidol levels and reduced haloperidol/haloperidol ratios between oral and depot therapy in these non-smoking patients. A loading dose regimen is needed due to the long elimination half-life of decanoate of 26 days otherwise steady-state condition will not occur until 3-4 months of therapy. Patients were maintained on monthly depot treatment for 40 weeks after the loading dose regimen and only one patient relapsed during treatment despite dosage increases. The formation of reduced haloperidol remained consistent for oral and depot haloperidol treatment.

Original languageEnglish
Pages (from-to)73-86
Number of pages14
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Volume20
Issue number1
DOIs
StatePublished - Jan 1996

Keywords

  • haloperidol
  • haloperidol decanoate
  • plasma concentrations
  • reduced haloperidol
  • reduced haloperidol/haloperidol ratios

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