@article{d731a189df7d4ce69b7493d8e2085cb6,
title = "Guidelines for the measurement of vascular function and structure in isolated arteries and veins",
abstract = "The measurement of vascular function in isolated vessels has revealed important insights into the structural, functional, and biomechanical features of the normal and diseased cardiovascular system and has provided a molecular understanding of the cells that constitutes arteries and veins and their interaction. Further, this approach has allowed the discovery of vital pharmacological treatments for cardiovascular diseases. However, the expansion of the vascular physiology field has also brought new concerns over scientific rigor and reproducibility. Therefore, it is appropriate to set guidelines for the best practices of evaluating vascular function in isolated vessels. These guidelines are a comprehensive document detailing the best practices and pitfalls for the assessment of function in large and small arteries and veins. Herein, we bring together experts in the field of vascular physiology with the purpose of developing guidelines for evaluating ex vivo vascular function. By using this document, vascular physiologists will have consistency among methodological approaches, producing more reliable and reproducible results.",
keywords = "Arteries, Contraction, Methods, Relaxation, Veins",
author = "Wenceslau, {Camilla F.} and McCarthy, {Cameron G.} and Scott Earley and England, {Sarah K.} and Filosa, {Jessica A.} and Styliani Goulopoulou and Gutterman, {David D.} and Isakson, {Brant E.} and Kanagy, {Nancy L.} and Martinez-Lemus, {Luis A.} and Sonkusare, {Swapnil K.} and Pratish Thakore and Trask, {Aaron J.} and Watts, {Stephanie W.} and {Clinton Webb}, R.",
note = "Funding Information: This work was supported by National Institutes of Health Grants R00GM118885 and R01HL149762 (to C.F.W.); K99HL151889 (to C.G. M.); R01HL091905, R01HL137852, R01HL139585, R01HL146054, RF1NS110044, R61NS115132, and P20GM130459 (to S.E.); R01HD037831, R01HD096737, and R01HD088097 (to S.K.E.); R01NS082521 (to J.A.F.); R01HL146562 (to S.G.); R01HL135901 (to D.D.G.); R01HL088554 and R01HL137112 (to B.E.I.); R01HL123301, R01HL121871, and R01ES014639 (to N.L.K.); R01 HL088105 (to L.A. M-L.); R01HL142808 and R01HL146914 (to S.K.S); R00HL116769, R21EB026518, and S10OD023438 (to A.J.T.); R01HL151413 (to S.W. W.); and P01HL134604, DK076169, and DK115255 (to R.C.W.) and The Abigail Wexner Research Institute at Nationwide Children{\textquoteright}s Hospital (to A.J.T.). Publisher Copyright: {\textcopyright} 2021 American Physiological Society. All rights reserved.",
year = "2021",
month = jul,
doi = "10.1152/ajpheart.01021.2020",
language = "English",
volume = "321",
pages = "H77--H111",
journal = "American Journal of Physiology - Heart and Circulatory Physiology",
issn = "0363-6135",
publisher = "American Physiological Society",
number = "1",
}