Guideline-concordant lung cancer care and associated health outcomes among elderly patients in the United States

Pramit A. Nadpara, S. Suresh Madhavan, Cindy Tworek, Usha Sambamoorthi, Michael Hendryx, Mohammed Almubarak

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Objectives: In the United States (US), the elderly carry a disproportionate burden of lung cancer. Although evidence-based guidelines for lung cancer care have been published, lack of high quality care still remains a concern among the elderly. This study comprehensively evaluates the variations in guideline-concordant lung cancer care among elderly in the US. Materials and Methods: Using the Surveillance, Epidemiology, and End Results (SEER)-Medicare database (2002-2007), we identified elderly patients (aged ≥. 65. years) with lung cancer (n. =. 42,323) and categorized them by receipt of guideline-concordant care, using evidence-based guidelines from the American College of Chest Physicians. A hierarchical generalized logistic model was constructed to identify variables associated with receipt of guideline-concordant care. Kaplan-Meier analysis and Log Rank test were used for estimation and comparison of the three-year survival. Multivariate Cox proportional hazards model was constructed to estimate lung cancer mortality risk associated with receipt of guideline-discordant care. Results: Only less than half of all patients (44.7%) received guideline-concordant care in the study population. The likelihood of receiving guideline-concordant care significantly decreased with increasing age, non-white race, higher comorbidity score, and lower income. Three-year median survival time significantly increased (exceeded 487. days) in patients receiving guideline-concordant care. Adjusted lung cancer mortality risk significantly increased by 91% (HR. =. 1.91, 95% CI: 1.82-2.00) among patients receiving guideline-discordant care. Conclusion: This study highlights the critical need to address disparities in receipt of guideline-concordant lung cancer care among elderly. Although lung cancer diagnostic and management services are covered under the Medicare program, underutilization of these services is a concern.

Original languageEnglish
Pages (from-to)101-110
Number of pages10
JournalJournal of Geriatric Oncology
Volume6
Issue number2
DOIs
StatePublished - 1 Mar 2015

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Lung Neoplasms
Guidelines
Delivery of Health Care
Medicare
Diagnostic Services
Survival
Mortality
Quality of Health Care
Kaplan-Meier Estimate
Proportional Hazards Models
Comorbidity
Epidemiology
Logistic Models
Databases

Keywords

  • Cancer
  • Disparities
  • Elderly
  • Guidelines
  • Lung
  • Medicare
  • Treatment

Cite this

Nadpara, Pramit A. ; Madhavan, S. Suresh ; Tworek, Cindy ; Sambamoorthi, Usha ; Hendryx, Michael ; Almubarak, Mohammed. / Guideline-concordant lung cancer care and associated health outcomes among elderly patients in the United States. In: Journal of Geriatric Oncology. 2015 ; Vol. 6, No. 2. pp. 101-110.
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abstract = "Objectives: In the United States (US), the elderly carry a disproportionate burden of lung cancer. Although evidence-based guidelines for lung cancer care have been published, lack of high quality care still remains a concern among the elderly. This study comprehensively evaluates the variations in guideline-concordant lung cancer care among elderly in the US. Materials and Methods: Using the Surveillance, Epidemiology, and End Results (SEER)-Medicare database (2002-2007), we identified elderly patients (aged ≥. 65. years) with lung cancer (n. =. 42,323) and categorized them by receipt of guideline-concordant care, using evidence-based guidelines from the American College of Chest Physicians. A hierarchical generalized logistic model was constructed to identify variables associated with receipt of guideline-concordant care. Kaplan-Meier analysis and Log Rank test were used for estimation and comparison of the three-year survival. Multivariate Cox proportional hazards model was constructed to estimate lung cancer mortality risk associated with receipt of guideline-discordant care. Results: Only less than half of all patients (44.7{\%}) received guideline-concordant care in the study population. The likelihood of receiving guideline-concordant care significantly decreased with increasing age, non-white race, higher comorbidity score, and lower income. Three-year median survival time significantly increased (exceeded 487. days) in patients receiving guideline-concordant care. Adjusted lung cancer mortality risk significantly increased by 91{\%} (HR. =. 1.91, 95{\%} CI: 1.82-2.00) among patients receiving guideline-discordant care. Conclusion: This study highlights the critical need to address disparities in receipt of guideline-concordant lung cancer care among elderly. Although lung cancer diagnostic and management services are covered under the Medicare program, underutilization of these services is a concern.",
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Guideline-concordant lung cancer care and associated health outcomes among elderly patients in the United States. / Nadpara, Pramit A.; Madhavan, S. Suresh; Tworek, Cindy; Sambamoorthi, Usha; Hendryx, Michael; Almubarak, Mohammed.

In: Journal of Geriatric Oncology, Vol. 6, No. 2, 01.03.2015, p. 101-110.

Research output: Contribution to journalArticle

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AU - Madhavan, S. Suresh

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AB - Objectives: In the United States (US), the elderly carry a disproportionate burden of lung cancer. Although evidence-based guidelines for lung cancer care have been published, lack of high quality care still remains a concern among the elderly. This study comprehensively evaluates the variations in guideline-concordant lung cancer care among elderly in the US. Materials and Methods: Using the Surveillance, Epidemiology, and End Results (SEER)-Medicare database (2002-2007), we identified elderly patients (aged ≥. 65. years) with lung cancer (n. =. 42,323) and categorized them by receipt of guideline-concordant care, using evidence-based guidelines from the American College of Chest Physicians. A hierarchical generalized logistic model was constructed to identify variables associated with receipt of guideline-concordant care. Kaplan-Meier analysis and Log Rank test were used for estimation and comparison of the three-year survival. Multivariate Cox proportional hazards model was constructed to estimate lung cancer mortality risk associated with receipt of guideline-discordant care. Results: Only less than half of all patients (44.7%) received guideline-concordant care in the study population. The likelihood of receiving guideline-concordant care significantly decreased with increasing age, non-white race, higher comorbidity score, and lower income. Three-year median survival time significantly increased (exceeded 487. days) in patients receiving guideline-concordant care. Adjusted lung cancer mortality risk significantly increased by 91% (HR. =. 1.91, 95% CI: 1.82-2.00) among patients receiving guideline-discordant care. Conclusion: This study highlights the critical need to address disparities in receipt of guideline-concordant lung cancer care among elderly. Although lung cancer diagnostic and management services are covered under the Medicare program, underutilization of these services is a concern.

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