Growth Factors and Stroke

David A. Greenberg; Kunlin Jin

doi:10.1016/j.nurx.2006.08.003

Growth Factors and Stroke

David A. Greenberg, Kunlin Jin

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Current options for the treatment of stroke are extremely limited, partly because of the rapidity with which brain cells die when deprived of their blood supply. Several recent studies suggest that growth factors can produce improvement in animal models of stroke, even when administered at postischemic intervals of many hours to days, when conventional neuroprotective approaches are typically futile. Several growth factors can access the brain after systemic administration, making them more attractive as therapeutic agents. Finally, growth factors are key mediators of neurogenesis in the adult brain, which could have a role in brain repair and functional recovery following stroke.

Original language	English
Pages (from-to)	458-465
Number of pages	8
Journal	NeuroRx
Volume	3
Issue number	4
DOIs	https://doi.org/10.1016/j.nurx.2006.08.003
State	Published - Oct 2006

Keywords

Stroke
growth factor
ischemia
neurogenesis
neuroprotection

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10.1016/j.nurx.2006.08.003

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title = "Growth Factors and Stroke",

abstract = "Current options for the treatment of stroke are extremely limited, partly because of the rapidity with which brain cells die when deprived of their blood supply. Several recent studies suggest that growth factors can produce improvement in animal models of stroke, even when administered at postischemic intervals of many hours to days, when conventional neuroprotective approaches are typically futile. Several growth factors can access the brain after systemic administration, making them more attractive as therapeutic agents. Finally, growth factors are key mediators of neurogenesis in the adult brain, which could have a role in brain repair and functional recovery following stroke.",

keywords = "Stroke, growth factor, ischemia, neurogenesis, neuroprotection",

author = "Greenberg, {David A.} and Kunlin Jin",

note = "Funding Information: This work was supported by NINDS R01NS44921 (D.A.G.) and NIA R01AG21980 (K.L.J.).",

year = "2006",

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AU - Greenberg, David A.

AU - Jin, Kunlin

N1 - Funding Information: This work was supported by NINDS R01NS44921 (D.A.G.) and NIA R01AG21980 (K.L.J.).

PY - 2006/10

Y1 - 2006/10

N2 - Current options for the treatment of stroke are extremely limited, partly because of the rapidity with which brain cells die when deprived of their blood supply. Several recent studies suggest that growth factors can produce improvement in animal models of stroke, even when administered at postischemic intervals of many hours to days, when conventional neuroprotective approaches are typically futile. Several growth factors can access the brain after systemic administration, making them more attractive as therapeutic agents. Finally, growth factors are key mediators of neurogenesis in the adult brain, which could have a role in brain repair and functional recovery following stroke.

AB - Current options for the treatment of stroke are extremely limited, partly because of the rapidity with which brain cells die when deprived of their blood supply. Several recent studies suggest that growth factors can produce improvement in animal models of stroke, even when administered at postischemic intervals of many hours to days, when conventional neuroprotective approaches are typically futile. Several growth factors can access the brain after systemic administration, making them more attractive as therapeutic agents. Finally, growth factors are key mediators of neurogenesis in the adult brain, which could have a role in brain repair and functional recovery following stroke.

KW - Stroke

KW - growth factor

KW - ischemia

KW - neurogenesis

KW - neuroprotection

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SP - 458

EP - 465

JO - NeuroRx

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Growth Factors and Stroke

Abstract

Keywords

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