Green Tea Polyphenol Prevents Diabetic Rats from Acute Kidney Injury after Cardiopulmonary Bypass Presented at the American Heart Association Scientific Session, Chicago, IL, Nov 15-19, 2014.

Masaki Funamoto, Hidetoshi Masumoto, Koji Takaori, Tomofumi Taki, Shuji Setozaki, Kazuhiro Yamazaki, Kenji Minakata, Tadashi Ikeda, Suong Hyu Hyon, Ryuzo Sakata

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Background Acute kidney injury (AKI) is a common complication accompanying cardiopulmonary bypass (CPB) and is independently associated with increased morbidity and death. Diabetes mellitus increases the risk for AKI after CPB. Epigallocatechin-3-gallate (EGCG) is a major component of the polyphenolic fraction of green tea, which possesses cardioprotective activities, as previously reported. We hypothesized that EGCG also possesses a renoprotective effect through its diverse biochemical properties and assessed the effect on renal function after CPB for diabetic rats. Methods Goto-Kakizaki rats developing type 2 diabetes mellitus were randomly assigned to one of the following groups: sham (n = 10), CPB (CPB alone, n = 9), or EGCG (CPB + EGCG, n = 10). CPB was conducted for 30 minutes at a flow rate of 100 mL/kg/min in the CPB and EGCG groups. Rats assigned to the EGCG group were administrated EGCG solution orally for 2 weeks before CPB. We evaluated renal biochemical or histologic changes at 24 hours after CPB. Results Compared with the CPB group, the EGCG group exhibited milder tubular injury histologically (p < 0.0001) and reduced expression of kidney injury molecule-1, a biomarker for renal tubular injury (p < 0.0001) and 8-hydroxy-2′-deoxyguanosine (p < 0.01), indicating attenuated oxidant stress. Conclusions Preoperative oral administration of EGCG ameliorates AKI in a CPB model of diabetic rats through antioxidative properties. This simple method could be applied in a clinical setting as a prophylactic renal protection against AKI after CPB, especially for high-risk patients with diabetes mellitus.

Original languageEnglish
Pages (from-to)1507-1513
Number of pages7
JournalAnnals of Thoracic Surgery
Volume101
Issue number4
DOIs
StatePublished - 1 Apr 2016

Fingerprint

Dive into the research topics of 'Green Tea Polyphenol Prevents Diabetic Rats from Acute Kidney Injury after Cardiopulmonary Bypass Presented at the American Heart Association Scientific Session, Chicago, IL, Nov 15-19, 2014.'. Together they form a unique fingerprint.

Cite this