Abstract
Goodpasture's syndrome, the syndromic manifestation of antiglomerular basement membrane (anti-GBM) disease, is an uncommon autoimmune phenomenon that typically presents with lung and renal pathology. The classic patient is young with few comorbidities and typically presents dramatically with diffuse alveolar hemorrhage and/or rapid unexplained kidney failure following respiratory infection. Serological tests are traditionally helpful in establishing the diagnosis, but rare cases of anti-GBM disease may be negative for associated serological markers, namely anti-GBM antibody. This case illustrates the classic clinical features of the pulmonary manifestations of anti-GBM disease with negative serological markers confirmed by immunofluorescence of alveolar basement membrane sampled at autopsy.
Original language | English |
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Pages (from-to) | 109-112 |
Number of pages | 4 |
Journal | Pathology Case Reviews |
Volume | 12 |
Issue number | 3 |
DOIs | |
State | Published - May 2007 |
Keywords
- Anti-GBM disease
- Goodpasture's syndrome