Abstract
Aim: Phytoestrogens, such as glycinol, have recently gained significant attention as an alternative therapy for osteoporosis due to their structural similarity to estradiol and their bone-generating potential. Methods: The osteogenic effects of glycinol were investigated in human bone marrow mesenchymal stem cells (BMSCs) derived from older (>50 years old) and younger subjects (<25 years old). Results: BMSCs isolated from older donors demonstrated reduced osteogenesis. 17β-estradiol and glycinol exposure rescued the age-related reduction in osteogenic differentiation of BMSCs. These results correlated with the induction of osteogenic genes and estrogen receptor-α (ER-α) following glycinol treatment. ER antagonist studies further support that glycinol promotes osteogenesis through ER signaling. Conclusion: The results from these studies support investigating glycinol as a potential preventive or treatment for osteoporosis.
Original language | English |
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Pages (from-to) | 513-524 |
Number of pages | 12 |
Journal | Regenerative Medicine |
Volume | 12 |
Issue number | 5 |
DOIs | |
State | Published - Jul 2017 |
Keywords
- Adult stem cells
- Age-related bone loss
- BMSCs
- Estrogen receptor
- Glycinol
- Osteogenesis
- Phytoestrogens