Glycinol enhances osteogenic differentiation and attenuates the effects of age on mesenchymal stem cells

Amy L. Strong; Robert B. Jones; Julie Glowacki; Stephen M. Boue; Matthew E. Burow; Bruce A. Bunnell

doi:10.2217/rme-2016-0148

Glycinol enhances osteogenic differentiation and attenuates the effects of age on mesenchymal stem cells

Amy L. Strong, Robert B. Jones, Julie Glowacki, Stephen M. Boue, Matthew E. Burow, Bruce A. Bunnell

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Aim: Phytoestrogens, such as glycinol, have recently gained significant attention as an alternative therapy for osteoporosis due to their structural similarity to estradiol and their bone-generating potential. Methods: The osteogenic effects of glycinol were investigated in human bone marrow mesenchymal stem cells (BMSCs) derived from older (>50 years old) and younger subjects (<25 years old). Results: BMSCs isolated from older donors demonstrated reduced osteogenesis. 17β-estradiol and glycinol exposure rescued the age-related reduction in osteogenic differentiation of BMSCs. These results correlated with the induction of osteogenic genes and estrogen receptor-α (ER-α) following glycinol treatment. ER antagonist studies further support that glycinol promotes osteogenesis through ER signaling. Conclusion: The results from these studies support investigating glycinol as a potential preventive or treatment for osteoporosis.

Original language	English
Pages (from-to)	513-524
Number of pages	12
Journal	Regenerative Medicine
Volume	12
Issue number	5
DOIs	https://doi.org/10.2217/rme-2016-0148
State	Published - Jul 2017

Keywords

Adult stem cells
Age-related bone loss
BMSCs
Estrogen receptor
Glycinol
Osteogenesis
Phytoestrogens

Access to Document

10.2217/rme-2016-0148

Cite this

@article{97df2da1e3824ad0b0759b80262ec745,

title = "Glycinol enhances osteogenic differentiation and attenuates the effects of age on mesenchymal stem cells",

abstract = "Aim: Phytoestrogens, such as glycinol, have recently gained significant attention as an alternative therapy for osteoporosis due to their structural similarity to estradiol and their bone-generating potential. Methods: The osteogenic effects of glycinol were investigated in human bone marrow mesenchymal stem cells (BMSCs) derived from older (>50 years old) and younger subjects (<25 years old). Results: BMSCs isolated from older donors demonstrated reduced osteogenesis. 17β-estradiol and glycinol exposure rescued the age-related reduction in osteogenic differentiation of BMSCs. These results correlated with the induction of osteogenic genes and estrogen receptor-α (ER-α) following glycinol treatment. ER antagonist studies further support that glycinol promotes osteogenesis through ER signaling. Conclusion: The results from these studies support investigating glycinol as a potential preventive or treatment for osteoporosis.",

keywords = "Adult stem cells, Age-related bone loss, BMSCs, Estrogen receptor, Glycinol, Osteogenesis, Phytoestrogens",

author = "Strong, {Amy L.} and Jones, {Robert B.} and Julie Glowacki and Boue, {Stephen M.} and Burow, {Matthew E.} and Bunnell, {Bruce A.}",

note = "Publisher Copyright: {\textcopyright} 2017 Future Medicine Ltd.",

year = "2017",

month = jul,

doi = "10.2217/rme-2016-0148",

language = "English",

volume = "12",

pages = "513--524",

journal = "Regenerative Medicine",

issn = "1746-0751",

publisher = "Future Medicine Ltd.",

number = "5",

}

TY - JOUR

T1 - Glycinol enhances osteogenic differentiation and attenuates the effects of age on mesenchymal stem cells

AU - Strong, Amy L.

AU - Jones, Robert B.

AU - Glowacki, Julie

AU - Boue, Stephen M.

AU - Burow, Matthew E.

AU - Bunnell, Bruce A.

PY - 2017/7

Y1 - 2017/7

N2 - Aim: Phytoestrogens, such as glycinol, have recently gained significant attention as an alternative therapy for osteoporosis due to their structural similarity to estradiol and their bone-generating potential. Methods: The osteogenic effects of glycinol were investigated in human bone marrow mesenchymal stem cells (BMSCs) derived from older (>50 years old) and younger subjects (<25 years old). Results: BMSCs isolated from older donors demonstrated reduced osteogenesis. 17β-estradiol and glycinol exposure rescued the age-related reduction in osteogenic differentiation of BMSCs. These results correlated with the induction of osteogenic genes and estrogen receptor-α (ER-α) following glycinol treatment. ER antagonist studies further support that glycinol promotes osteogenesis through ER signaling. Conclusion: The results from these studies support investigating glycinol as a potential preventive or treatment for osteoporosis.

AB - Aim: Phytoestrogens, such as glycinol, have recently gained significant attention as an alternative therapy for osteoporosis due to their structural similarity to estradiol and their bone-generating potential. Methods: The osteogenic effects of glycinol were investigated in human bone marrow mesenchymal stem cells (BMSCs) derived from older (>50 years old) and younger subjects (<25 years old). Results: BMSCs isolated from older donors demonstrated reduced osteogenesis. 17β-estradiol and glycinol exposure rescued the age-related reduction in osteogenic differentiation of BMSCs. These results correlated with the induction of osteogenic genes and estrogen receptor-α (ER-α) following glycinol treatment. ER antagonist studies further support that glycinol promotes osteogenesis through ER signaling. Conclusion: The results from these studies support investigating glycinol as a potential preventive or treatment for osteoporosis.

KW - Adult stem cells

KW - Age-related bone loss

KW - BMSCs

KW - Estrogen receptor

KW - Glycinol

KW - Osteogenesis

KW - Phytoestrogens

UR - http://www.scopus.com/inward/record.url?scp=85028866176&partnerID=8YFLogxK

U2 - 10.2217/rme-2016-0148

DO - 10.2217/rme-2016-0148

M3 - Article

C2 - 28718749

AN - SCOPUS:85028866176

SN - 1746-0751

VL - 12

SP - 513

EP - 524

JO - Regenerative Medicine

JF - Regenerative Medicine

IS - 5

ER -

Glycinol enhances osteogenic differentiation and attenuates the effects of age on mesenchymal stem cells

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this