Glycinol enhances osteogenic differentiation and attenuates the effects of age on mesenchymal stem cells

Amy L. Strong, Robert B. Jones, Julie Glowacki, Stephen M. Boue, Matthew E. Burow, Bruce A. Bunnell

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Aim: Phytoestrogens, such as glycinol, have recently gained significant attention as an alternative therapy for osteoporosis due to their structural similarity to estradiol and their bone-generating potential. Methods: The osteogenic effects of glycinol were investigated in human bone marrow mesenchymal stem cells (BMSCs) derived from older (>50 years old) and younger subjects (<25 years old). Results: BMSCs isolated from older donors demonstrated reduced osteogenesis. 17β-estradiol and glycinol exposure rescued the age-related reduction in osteogenic differentiation of BMSCs. These results correlated with the induction of osteogenic genes and estrogen receptor-α (ER-α) following glycinol treatment. ER antagonist studies further support that glycinol promotes osteogenesis through ER signaling. Conclusion: The results from these studies support investigating glycinol as a potential preventive or treatment for osteoporosis.

Original languageEnglish
Pages (from-to)513-524
Number of pages12
JournalRegenerative Medicine
Volume12
Issue number5
DOIs
StatePublished - Jul 2017

Keywords

  • Adult stem cells
  • Age-related bone loss
  • BMSCs
  • Estrogen receptor
  • Glycinol
  • Osteogenesis
  • Phytoestrogens

Fingerprint Dive into the research topics of 'Glycinol enhances osteogenic differentiation and attenuates the effects of age on mesenchymal stem cells'. Together they form a unique fingerprint.

Cite this