Glutaredoxin 1 (Grx1) protects human retinal pigment epithelial cells from oxidative damage by preventing AKT glutathionylation

Keyphrases

• Akt Activation 8%
• Akt Phosphorylation 8%
• Annexin V/propidium Iodide 8%
• Antioxidant System 8%
• Apoptosis 33%
• ARPE-19 Cells 16%
• Cell Viability 8%
• Cell Viability Loss 8%
• Co-immunoprecipitation (co-IP) 8%
• Double Staining 8%
• Endogenous Antioxidant System 8%
• Gene Knockout 8%
• Glutaredoxin 100%
• Glutathionylation 100%
• H2O2-induced Apoptosis 8%
• Hydrogen Peroxide 33%
• Immunoblotting 16%
• Overexpression 25%
• Oxidative Damage 100%
• Oxidoreductase 8%
• Pharmacological Targets 8%
• Phospho-Akt 8%
• Physiological Function 8%
• Plasmid 16%
• Protective Capacity 8%
• Protein Kinase B 8%
• Protein Kinase B/Akt 8%
• Retinal Degeneration 8%
• Retinal pigment Epithelial 8%
• Retinal pigment Epithelium 100%
• S-glutathionylation 8%
• Small Interfering RNA (siRNA) 16%
• Transfected Cells 8%
• Western Blot 8%

Biochemistry, Genetics and Molecular Biology

• Cell Viability 16%
• Gene Knockdown 8%
• Glutaredoxin 100%
• Glutathionylation 100%
• Hydrogen Peroxide 41%
• Immunoblotting 16%
• Immunoprecipitation 8%
• Lipocortin 8%
• Oxidoreductase 8%
• Plasmid 16%
• Propidium Iodide 8%
• Protein Kinase B 16%
• Small Interfering RNA 16%
• Western Blotting 8%