TY - JOUR
T1 - [Glu2]TRH dose-dependently attenuates TRH-evoked analeptic effect in mice
AU - Nguyen, Vien
AU - Zharikova, Alevtina D.
AU - Prokai-Tatrai, Katalin
AU - Prokai, Laszlo
N1 - Funding Information:
The authors are indebted to the inspiring scientific environment at the Department of Medicinal Chemistry, College of Pharmacy, University of Florida, where majority of the research reported here was conducted. This research was supported by a grant ( MH59360 to L.P.) from the National Institute of Health .
PY - 2010/4
Y1 - 2010/4
N2 - Thyrotropin-releasing hormone (TRH, pGlu-His-Pro-NH2) and the structurally related [Glu2]TRH (pGlu-Glu-Pro-NH2) are endogenous peptides with a plethora of actions in the central nervous system. Many centrally-mediated effects of TRH are shared with those of [Glu2]TRH, although the involvement of different receptors is presumed. The analeptic action is the best-known TRH-related central nervous system effect. While [Glu2]TRH itself is analeptic, its co-administration with TRH into mice produced a dose-dependent attenuation of TRH-evoked reversal of barbiturate-induced sleeping time. This finding is in agreement with our previous observations that [Glu2]TRH significantly attenuates TRH-induced hippocampal extracellular acetylcholine release. Taken together, [Glu2]TRH may be considered as a negative modulator for the cholinergic effect of TRH in the mouse brain.
AB - Thyrotropin-releasing hormone (TRH, pGlu-His-Pro-NH2) and the structurally related [Glu2]TRH (pGlu-Glu-Pro-NH2) are endogenous peptides with a plethora of actions in the central nervous system. Many centrally-mediated effects of TRH are shared with those of [Glu2]TRH, although the involvement of different receptors is presumed. The analeptic action is the best-known TRH-related central nervous system effect. While [Glu2]TRH itself is analeptic, its co-administration with TRH into mice produced a dose-dependent attenuation of TRH-evoked reversal of barbiturate-induced sleeping time. This finding is in agreement with our previous observations that [Glu2]TRH significantly attenuates TRH-induced hippocampal extracellular acetylcholine release. Taken together, [Glu2]TRH may be considered as a negative modulator for the cholinergic effect of TRH in the mouse brain.
KW - Acetylcholine
KW - Analeptic effect
KW - Endogenous analogue
KW - Thyrotropin-releasing hormone
UR - http://www.scopus.com/inward/record.url?scp=77952302074&partnerID=8YFLogxK
U2 - 10.1016/j.brainresbull.2010.02.007
DO - 10.1016/j.brainresbull.2010.02.007
M3 - Article
C2 - 20188155
AN - SCOPUS:77952302074
SN - 0361-9230
VL - 82
SP - 83
EP - 86
JO - Brain Research Bulletin
JF - Brain Research Bulletin
IS - 1-2
ER -