[Glu2]TRH dose-dependently attenuates TRH-evoked analeptic effect in mice

Vien Nguyen, Alevtina D. Zharikova, Katalin Prokai-Tatrai, Laszlo Prokai

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Thyrotropin-releasing hormone (TRH, pGlu-His-Pro-NH2) and the structurally related [Glu2]TRH (pGlu-Glu-Pro-NH2) are endogenous peptides with a plethora of actions in the central nervous system. Many centrally-mediated effects of TRH are shared with those of [Glu2]TRH, although the involvement of different receptors is presumed. The analeptic action is the best-known TRH-related central nervous system effect. While [Glu2]TRH itself is analeptic, its co-administration with TRH into mice produced a dose-dependent attenuation of TRH-evoked reversal of barbiturate-induced sleeping time. This finding is in agreement with our previous observations that [Glu2]TRH significantly attenuates TRH-induced hippocampal extracellular acetylcholine release. Taken together, [Glu2]TRH may be considered as a negative modulator for the cholinergic effect of TRH in the mouse brain.

Original languageEnglish
Pages (from-to)83-86
Number of pages4
JournalBrain Research Bulletin
Volume82
Issue number1-2
DOIs
StatePublished - Apr 2010

Keywords

  • Acetylcholine
  • Analeptic effect
  • Endogenous analogue
  • Thyrotropin-releasing hormone

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