Glial scar formation occurs in the human brain after ischemic stroke

Lijie Huang, Zhe Bao Wu, Qichuan ZhuGe, Wei Ming Zheng, Bei Shao, Brian Wang, Fen Sun, Kunlin Jin

Research output: Contribution to journalArticle

65 Scopus citations

Abstract

Reactive gliosis and glial scar formation have been evidenced in the animal model of ischemic stroke, but not in human ischemic brain. Here, we have found that GFAP, ED1 and chondroitin sulphate proteoglycans (CSPG) expression were significantly increased in the cortical peri-infarct regions after ischemic stroke, compared with adjacent normal tissues and control subjects. Double immunolabeling showed that GFAP-positive reactive astrocytes in the peri-infarct region expressed CSPG, but showed no overlap with ED1-positive activated microglia. Our findings suggest that reactive gliosis and glial scar formation as seen in animal models of stroke are reflective of what occurs in the human brain after an ischemic injury.

Original languageEnglish
Pages (from-to)344-348
Number of pages5
JournalInternational Journal of Medical Sciences
Volume11
Issue number4
DOIs
StatePublished - 11 Feb 2014

Keywords

  • Glial scar
  • Human
  • Ischemic stroke
  • Patients
  • Reactive gliosis

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