TY - JOUR
T1 - Ginkgo biloba extract (EGb 761) protects human low density lipoproteins against oxidative modification mediated by copper
AU - Yan, Liang Jun
AU - Droy-Lefaix, Marie Therese
AU - Packer, Lester
PY - 1995
Y1 - 1995
N2 - The antioxidant effects of Ginkgo biloba extract (EGb 761) on copper-mediated human low density lipoprotein (LDL) oxidative modification were evaluated by several techniques. Human LDL (0.5 mg/ml) in phosphate buffered saline, pH 7.4, was incubated with 10 μM cupric sulfate at 37°C under air for 8 hours and 24 hours in the presence of varying concentrations of EGb 761. Increases in LDL apoB carbonylation, lipid peroxidation, apoB electrophoretic mobility and LDL fluorescence were all inhibited when the incubation mixture contained EGb 761 at concentrations less than 100 μg/ml. This inhibition was EGb 761-concentration-dependent. Thus, EGb 761 has powerful antioxidant effects on copper-mediated LDL oxidative modification.
AB - The antioxidant effects of Ginkgo biloba extract (EGb 761) on copper-mediated human low density lipoprotein (LDL) oxidative modification were evaluated by several techniques. Human LDL (0.5 mg/ml) in phosphate buffered saline, pH 7.4, was incubated with 10 μM cupric sulfate at 37°C under air for 8 hours and 24 hours in the presence of varying concentrations of EGb 761. Increases in LDL apoB carbonylation, lipid peroxidation, apoB electrophoretic mobility and LDL fluorescence were all inhibited when the incubation mixture contained EGb 761 at concentrations less than 100 μg/ml. This inhibition was EGb 761-concentration-dependent. Thus, EGb 761 has powerful antioxidant effects on copper-mediated LDL oxidative modification.
UR - http://www.scopus.com/inward/record.url?scp=0029128864&partnerID=8YFLogxK
U2 - 10.1006/bbrc.1995.1978
DO - 10.1006/bbrc.1995.1978
M3 - Article
C2 - 7626049
AN - SCOPUS:0029128864
SN - 0006-291X
VL - 212
SP - 360
EP - 366
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 2
ER -