Genomics-guided discovery of thailanstatins A, B, and C as pre-mRNA splicing inhibitors and antiproliferative agents from Burkholderia thailandensis MSMB43

Keyphrases

• Burkholderia Thailandensis 100%
• RNA Splicing 100%
• Antiproliferative Activity 100%
• Thailanstatin 100%
• Guided Discovery 100%
• Splicing Inhibitors 100%
• Inhibitor Agent 100%
• Spliceosome Inhibitors 33%
• Growth Inhibition 16%
• Regulatory Genes 16%
• Genome Sequencing 16%
• Nonribosomal Peptide Synthetase 16%
• Polyketide Synthase 16%
• Hybrid Polyketide 16%
• B. Thailandensis 16%
• Fermentation Broth 16%
• Phosphate Buffer 16%
• FR901464 16%
• Cancer Cell Lines 16%
• Pseudomonas 16%
• Half Maximal Inhibitory Concentration 16%
• Cryptic Biosynthetic Gene Cluster 16%
• In Vitro Assay 16%
• Maximal Growth 16%
• Carboxyl 16%
• Cryptic Gene Cluster 16%
• New Chemical Entities 16%
• Activity Information 16%
• Inhibitory Concentration 16%
• Cultivation Conditions 16%
• Structure-activity 16%
• Cell Culture Assay 16%
• Chemical Optimization 16%
• Hydroxyl Group 16%
• Biosynthesized 16%
• Transcriptional Analysis 16%

Immunology and Microbiology

• Gene Cluster 100%
• Burkholderia thailandensis 100%
• RNA Splicing 100%
• Spliceosome 100%
• Cell Culture 50%
• IC50 50%
• Cancer Cell Line 50%
• Antiproliferative Activity 50%
• Pseudomonas 50%
• GI50 50%

Pharmacology, Toxicology and Pharmaceutical Science

• Burkholderia thailandensis 100%
• Messenger RNA Precursor 100%
• Malignant Neoplasm 50%
• Buffer 50%
• Cell Culture 50%
• IC50 50%
• Nonribosomal Peptide Synthetase 50%
• Antiproliferative Activity 50%
• Polyketide Synthase 50%
• Hydroxyl Group 50%
• Pseudomonas 50%