Genomewide scan for gout in Taiwanese aborigines reveals linkage to chromosome 4q25

Li Shu Chuan Cheng, Shang Lun Chiang, Hung Pin Tu, Shun Jen Chang, Tsu Nai Wang, Allen Min Jen Ko, Ranajit Chakraborty, Ying Chin Ko

Research output: Contribution to journalArticle

49 Scopus citations

Abstract

Gout is a disorder of uric-acid metabolism. The Pacific Austronesian population, including Taiwanese aborigines, has a remarkably high prevalence of hyperuricemia and gout, which suggests a founder effect across the Pacific region. We report here a genomewide linkage study of 21 multiplex pedigrees with gout from an aboriginal tribe in Taiwan. From observations of familial clustering, early onset of gout, and clinically severe manifestations, we hypothesized that a major gene plays a role in this trait. Using 382 random polymorphic markers spread across 22 autosomes, we demonstrated a highly significant linkage for gout at marker D4S2623 on chromosome 4q25 (P = .0002 by nonparametric linkage [the NPLall statistic]; empirical P = .0006; LOD = 4.3, P = 4.4 × 10-6 by logistic regression). When alcohol consumption was included as a covariate in the model, the LOD score increased to 5.66 (P = 1.3 × 10-6). Quantitative traits, including serum uric acid and creatinine, also showed a moderate linkage to this region. To our knowledge, this is the first genome-scan report to identify a genetic locus harboring a gout-susceptibility gene.

Original languageEnglish
Pages (from-to)498-503
Number of pages6
JournalAmerican Journal of Human Genetics
Volume75
Issue number3
DOIs
StatePublished - Sep 2004

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    Cheng, L. S. C., Chiang, S. L., Tu, H. P., Chang, S. J., Wang, T. N., Ko, A. M. J., Chakraborty, R., & Ko, Y. C. (2004). Genomewide scan for gout in Taiwanese aborigines reveals linkage to chromosome 4q25. American Journal of Human Genetics, 75(3), 498-503. https://doi.org/10.1086/423429