Genetic variation of 15 autosomal microsatellite loci in a Tamil population from Tamil Nadu, Southern India

Kuppareddi Balamurugan; S. Kanthimathi; M. Vijaya; G. Suhasini; George Duncan; Martin Tracey; Bruce Budowle

doi:10.1016/j.legalmed.2010.07.004

Genetic variation of 15 autosomal microsatellite loci in a Tamil population from Tamil Nadu, Southern India

Kuppareddi Balamurugan, S. Kanthimathi, M. Vijaya, G. Suhasini, George Duncan, Martin Tracey, Bruce Budowle

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Abstract

The genetic profiles for 15 autosomal microsatellite loci were analyzed in a Tamil population from Southern India to study the genetic diversities and relatedness of this population with other national and global populations. Statistical analyses of the data revealed all loci were within Hardy-Weinberg Equilibrium (HWE) expectations with the exception of the locus D5S818 (p= 0.011). A significantly greater inter-individual variation (Fst. = 99%) observed within the individuals among the four subgroups in this study and low population differentiation (Fst. = 1%) suggests relative genetic closeness of these four subgroups. This indicates that the populations in the southern region of India might have a common ancestry or probably experienced high gene flow during the period of their coexistence. The Neighbor Joining tree derived from genetic distances of samples from this study and other national and global populations show clustering of all the Indian populations in one branch of the tree while the African and Middle Eastern populations cluster in a separate branch. Principal Co-ordinate Analysis of the genetic distance data show clustering similar to the NJ tree.

Original language	English
Pages (from-to)	320-323
Number of pages	4
Journal	Legal Medicine
Volume	12
Issue number	6
DOIs	https://doi.org/10.1016/j.legalmed.2010.07.004
State	Published - Nov 2010

Keywords

DNA frequency estimate
Gene diversity
Genetic distance
STR
South Indian population
Tamil population

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10.1016/j.legalmed.2010.07.004

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title = "Genetic variation of 15 autosomal microsatellite loci in a Tamil population from Tamil Nadu, Southern India",

abstract = "The genetic profiles for 15 autosomal microsatellite loci were analyzed in a Tamil population from Southern India to study the genetic diversities and relatedness of this population with other national and global populations. Statistical analyses of the data revealed all loci were within Hardy-Weinberg Equilibrium (HWE) expectations with the exception of the locus D5S818 (p= 0.011). A significantly greater inter-individual variation (Fst. = 99%) observed within the individuals among the four subgroups in this study and low population differentiation (Fst. = 1%) suggests relative genetic closeness of these four subgroups. This indicates that the populations in the southern region of India might have a common ancestry or probably experienced high gene flow during the period of their coexistence. The Neighbor Joining tree derived from genetic distances of samples from this study and other national and global populations show clustering of all the Indian populations in one branch of the tree while the African and Middle Eastern populations cluster in a separate branch. Principal Co-ordinate Analysis of the genetic distance data show clustering similar to the NJ tree.",

keywords = "DNA frequency estimate, Gene diversity, Genetic distance, STR, South Indian population, Tamil population",

author = "Kuppareddi Balamurugan and S. Kanthimathi and M. Vijaya and G. Suhasini and George Duncan and Martin Tracey and Bruce Budowle",

note = "Funding Information: The authors wish to thank Dr. A. Ramesh, Chairman, Department of Genetics, University of Madras, India for sharing the samples for this study. This study was partly supported by a startup grant for one of the authors (KB) from the University of Southern Mississippi, Hattiesburg, MS . Partial financial support was provided to the Department of Genetics, University of Madras by the Department of Biotechnology, Government of India . We thank Ms. Nicole Mullins, School of Criminal Justice, University of Southern Mississippi for technical assistance and data analysis. ",

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AU - Balamurugan, Kuppareddi

AU - Kanthimathi, S.

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AU - Suhasini, G.

AU - Duncan, George

AU - Tracey, Martin

AU - Budowle, Bruce

N1 - Funding Information: The authors wish to thank Dr. A. Ramesh, Chairman, Department of Genetics, University of Madras, India for sharing the samples for this study. This study was partly supported by a startup grant for one of the authors (KB) from the University of Southern Mississippi, Hattiesburg, MS . Partial financial support was provided to the Department of Genetics, University of Madras by the Department of Biotechnology, Government of India . We thank Ms. Nicole Mullins, School of Criminal Justice, University of Southern Mississippi for technical assistance and data analysis.

PY - 2010/11

Y1 - 2010/11

N2 - The genetic profiles for 15 autosomal microsatellite loci were analyzed in a Tamil population from Southern India to study the genetic diversities and relatedness of this population with other national and global populations. Statistical analyses of the data revealed all loci were within Hardy-Weinberg Equilibrium (HWE) expectations with the exception of the locus D5S818 (p= 0.011). A significantly greater inter-individual variation (Fst. = 99%) observed within the individuals among the four subgroups in this study and low population differentiation (Fst. = 1%) suggests relative genetic closeness of these four subgroups. This indicates that the populations in the southern region of India might have a common ancestry or probably experienced high gene flow during the period of their coexistence. The Neighbor Joining tree derived from genetic distances of samples from this study and other national and global populations show clustering of all the Indian populations in one branch of the tree while the African and Middle Eastern populations cluster in a separate branch. Principal Co-ordinate Analysis of the genetic distance data show clustering similar to the NJ tree.

AB - The genetic profiles for 15 autosomal microsatellite loci were analyzed in a Tamil population from Southern India to study the genetic diversities and relatedness of this population with other national and global populations. Statistical analyses of the data revealed all loci were within Hardy-Weinberg Equilibrium (HWE) expectations with the exception of the locus D5S818 (p= 0.011). A significantly greater inter-individual variation (Fst. = 99%) observed within the individuals among the four subgroups in this study and low population differentiation (Fst. = 1%) suggests relative genetic closeness of these four subgroups. This indicates that the populations in the southern region of India might have a common ancestry or probably experienced high gene flow during the period of their coexistence. The Neighbor Joining tree derived from genetic distances of samples from this study and other national and global populations show clustering of all the Indian populations in one branch of the tree while the African and Middle Eastern populations cluster in a separate branch. Principal Co-ordinate Analysis of the genetic distance data show clustering similar to the NJ tree.

KW - DNA frequency estimate

KW - Gene diversity

KW - Genetic distance

KW - STR

KW - South Indian population

KW - Tamil population

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Genetic variation of 15 autosomal microsatellite loci in a Tamil population from Tamil Nadu, Southern India

Abstract

Keywords

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