TY - JOUR
T1 - Genetic variation by birth cohorts in Mexican Americans of Starr County, Texas
AU - Cerda‐Flores, Ricardo M.
AU - Barton, Sara A.
AU - Hanis, Craig L.
AU - Chakraborty, Ranajit
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1994
Y1 - 1994
N2 - Mexican Americans residing in Starr County, Texas, were grouped by their year of birth (1896–1925, 1926–1955, and 1956–1985) to determine the extent of birth cohort‐related genetic variation within this population and the genetic differences, if any, from the Mexican population residing in the Metropolitan Monterrey Area (MMA), Nuevo León, México. Twenty‐one genetic markers were analyzed which indicate that the three birth cohort groups are genetically indistinguishable. Gene diversity analysis suggests that more than 99.8% of the total gene diversity can be attributed to variation between individuals within the birth cohort populations and that the subdivision by birth cohort has only a small contribution (0.18%) to the total gene diversity. Genetic admixture analysis indicates a predominant influence from the Spanish, and that the three birth cohort groups were similar in terms of contributions of this ancestral population. The genetic structure of the Mexican American population of Starr County was also similar to the Mexican population from the State of Nuevo León, México. These findings, together with previous results, suggest that the Mexican Americans of Starr County, Texas, classified by gender, birthplace, and age, are not genetically distinguishable and are similar to the Mexican populations of the State of Nuevo León. © 1994 Wiley‐Liss, Inc.
AB - Mexican Americans residing in Starr County, Texas, were grouped by their year of birth (1896–1925, 1926–1955, and 1956–1985) to determine the extent of birth cohort‐related genetic variation within this population and the genetic differences, if any, from the Mexican population residing in the Metropolitan Monterrey Area (MMA), Nuevo León, México. Twenty‐one genetic markers were analyzed which indicate that the three birth cohort groups are genetically indistinguishable. Gene diversity analysis suggests that more than 99.8% of the total gene diversity can be attributed to variation between individuals within the birth cohort populations and that the subdivision by birth cohort has only a small contribution (0.18%) to the total gene diversity. Genetic admixture analysis indicates a predominant influence from the Spanish, and that the three birth cohort groups were similar in terms of contributions of this ancestral population. The genetic structure of the Mexican American population of Starr County was also similar to the Mexican population from the State of Nuevo León, México. These findings, together with previous results, suggest that the Mexican Americans of Starr County, Texas, classified by gender, birthplace, and age, are not genetically distinguishable and are similar to the Mexican populations of the State of Nuevo León. © 1994 Wiley‐Liss, Inc.
UR - http://www.scopus.com/inward/record.url?scp=84995202652&partnerID=8YFLogxK
U2 - 10.1002/ajhb.1310060516
DO - 10.1002/ajhb.1310060516
M3 - Article
AN - SCOPUS:84995202652
SN - 1042-0533
VL - 6
SP - 669
EP - 674
JO - American Journal of Human Biology
JF - American Journal of Human Biology
IS - 5
ER -