TY - JOUR
T1 - Genetic variation at nine short tandem repeat loci in Chamorros and Filipinos from Guam
AU - Budowle, Bruce
AU - Defenbaugh, Debra A.
AU - Keys, Kathleen M.
PY - 2000/1/1
Y1 - 2000/1/1
N2 - Allele distributions for nine tetrameric short tandem repeat (STR) loci D3S1358, D5S818, D7S820, D8S1179, D13S317, D18S51, D21S11, FGA and vWA were determined in Chamorros and Filipinos residing in Guam. There was little evidence for departures from Hardy-Weinberg expectations (HWE) in any of the populations. Based on the exact test, the only locus that departs significantly from HWE is D8S1179 (p=0.005, Chamorros; p=0.030, Filipinos). There is little evidence for association of alleles between the loci in these databases. The number of pairwise locus departures from expectations is no more than would be expected by chance. The allelic frequency data are similar to comparable published data within the same population group (e.g., a comparison of Filipinos with Filipinos) and significantly different compared with other major population groups, such as African Americans, Caucasians, and Hispanics. The F(ST) estimate over all nine STR loci is 0.0090.
AB - Allele distributions for nine tetrameric short tandem repeat (STR) loci D3S1358, D5S818, D7S820, D8S1179, D13S317, D18S51, D21S11, FGA and vWA were determined in Chamorros and Filipinos residing in Guam. There was little evidence for departures from Hardy-Weinberg expectations (HWE) in any of the populations. Based on the exact test, the only locus that departs significantly from HWE is D8S1179 (p=0.005, Chamorros; p=0.030, Filipinos). There is little evidence for association of alleles between the loci in these databases. The number of pairwise locus departures from expectations is no more than would be expected by chance. The allelic frequency data are similar to comparable published data within the same population group (e.g., a comparison of Filipinos with Filipinos) and significantly different compared with other major population groups, such as African Americans, Caucasians, and Hispanics. The F(ST) estimate over all nine STR loci is 0.0090.
KW - Chamorro
KW - F(ST)
KW - Filipino
KW - Hardy-Weinberg expectations
KW - Linkage equilibrium
KW - PCR
KW - Population databases
KW - STR
UR - http://www.scopus.com/inward/record.url?scp=0034008974&partnerID=8YFLogxK
U2 - 10.1016/S1344-6223(00)80005-X
DO - 10.1016/S1344-6223(00)80005-X
M3 - Article
C2 - 12935462
AN - SCOPUS:0034008974
SN - 1344-6223
VL - 2
SP - 26
EP - 30
JO - Legal Medicine
JF - Legal Medicine
IS - 1
ER -