Genetic variation at nine short tandem repeat loci among islanders of the eastern Adriatic coast of Croatia

Irena Martinović Klarić, Marijana Peričić, Lovorka Barać Lauc, Branka Janićijević, Milovan Kubat, Dino Pavičić, Igor Rudan, Ning Wang, Lin Jin, Ranajit Chakraborty, Ranjan Deka, Pavao Rudan

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

We have analyzed the extent of genetic variation at nine autosomal short tandem repeat loci (D3S1358, VWA, FGA, TH01, TPOX, CSF1PO, D5S818, D13S317, D7S820) among six populations from Croatia: five distributed in the islands of the eastern Adriatic coast and one from the mainland. The purpose is to investigate the usefulness of these loci in detecting regional genetic differentiation in the studied populations. Significant heterogeneity among the island and mainland populations is revealed in the distributions of allele frequencies; however, the absolute magnitude of the coefficient of gene differentiation is small but significant. The summary measures of genetic variation, namely, heterozygosity, number of alleles, and allele size variance, do not indicate reduced genetic variation in the island populations compared to the mainland population. In contrast to the two measures of genetic variation, allele size variance and within-locus heterozygosity, the imbalance index (β) indicates evidence of recent expansion of population sizes in all islands and in the mainland. High mutation rates of the studied loci together with local drift effects are likely explanations for interisland genetic variation and the observed lack of reduced genetic diversity among the island populations.

Original languageEnglish
Pages (from-to)471-486
Number of pages16
JournalHuman Biology
Volume77
Issue number4
StatePublished - 1 Aug 2005

Fingerprint

Croatia
Microsatellite Repeats
genetic variation
Islands
microsatellite repeats
allele
coasts
loci
coast
Population
heterozygosity
Alleles
alleles
genetic differentiation
Mutation Rate
population size
Population Density
mutation
Gene Frequency
gene frequency

Keywords

  • CSF1PO
  • Croatia
  • D13S317
  • D3SI358
  • D5S818
  • D7S820
  • Dalmatian islands
  • Eastern Adriatic islands
  • FGA
  • Genetic variation
  • Short tandem repeats
  • TH01
  • TPOX
  • VWA

Cite this

Klarić, I. M., Peričić, M., Lauc, L. B., Janićijević, B., Kubat, M., Pavičić, D., ... Rudan, P. (2005). Genetic variation at nine short tandem repeat loci among islanders of the eastern Adriatic coast of Croatia. Human Biology, 77(4), 471-486.
Klarić, Irena Martinović ; Peričić, Marijana ; Lauc, Lovorka Barać ; Janićijević, Branka ; Kubat, Milovan ; Pavičić, Dino ; Rudan, Igor ; Wang, Ning ; Jin, Lin ; Chakraborty, Ranajit ; Deka, Ranjan ; Rudan, Pavao. / Genetic variation at nine short tandem repeat loci among islanders of the eastern Adriatic coast of Croatia. In: Human Biology. 2005 ; Vol. 77, No. 4. pp. 471-486.
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Klarić, IM, Peričić, M, Lauc, LB, Janićijević, B, Kubat, M, Pavičić, D, Rudan, I, Wang, N, Jin, L, Chakraborty, R, Deka, R & Rudan, P 2005, 'Genetic variation at nine short tandem repeat loci among islanders of the eastern Adriatic coast of Croatia', Human Biology, vol. 77, no. 4, pp. 471-486.

Genetic variation at nine short tandem repeat loci among islanders of the eastern Adriatic coast of Croatia. / Klarić, Irena Martinović; Peričić, Marijana; Lauc, Lovorka Barać; Janićijević, Branka; Kubat, Milovan; Pavičić, Dino; Rudan, Igor; Wang, Ning; Jin, Lin; Chakraborty, Ranajit; Deka, Ranjan; Rudan, Pavao.

In: Human Biology, Vol. 77, No. 4, 01.08.2005, p. 471-486.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Genetic variation at nine short tandem repeat loci among islanders of the eastern Adriatic coast of Croatia

AU - Klarić, Irena Martinović

AU - Peričić, Marijana

AU - Lauc, Lovorka Barać

AU - Janićijević, Branka

AU - Kubat, Milovan

AU - Pavičić, Dino

AU - Rudan, Igor

AU - Wang, Ning

AU - Jin, Lin

AU - Chakraborty, Ranajit

AU - Deka, Ranjan

AU - Rudan, Pavao

PY - 2005/8/1

Y1 - 2005/8/1

N2 - We have analyzed the extent of genetic variation at nine autosomal short tandem repeat loci (D3S1358, VWA, FGA, TH01, TPOX, CSF1PO, D5S818, D13S317, D7S820) among six populations from Croatia: five distributed in the islands of the eastern Adriatic coast and one from the mainland. The purpose is to investigate the usefulness of these loci in detecting regional genetic differentiation in the studied populations. Significant heterogeneity among the island and mainland populations is revealed in the distributions of allele frequencies; however, the absolute magnitude of the coefficient of gene differentiation is small but significant. The summary measures of genetic variation, namely, heterozygosity, number of alleles, and allele size variance, do not indicate reduced genetic variation in the island populations compared to the mainland population. In contrast to the two measures of genetic variation, allele size variance and within-locus heterozygosity, the imbalance index (β) indicates evidence of recent expansion of population sizes in all islands and in the mainland. High mutation rates of the studied loci together with local drift effects are likely explanations for interisland genetic variation and the observed lack of reduced genetic diversity among the island populations.

AB - We have analyzed the extent of genetic variation at nine autosomal short tandem repeat loci (D3S1358, VWA, FGA, TH01, TPOX, CSF1PO, D5S818, D13S317, D7S820) among six populations from Croatia: five distributed in the islands of the eastern Adriatic coast and one from the mainland. The purpose is to investigate the usefulness of these loci in detecting regional genetic differentiation in the studied populations. Significant heterogeneity among the island and mainland populations is revealed in the distributions of allele frequencies; however, the absolute magnitude of the coefficient of gene differentiation is small but significant. The summary measures of genetic variation, namely, heterozygosity, number of alleles, and allele size variance, do not indicate reduced genetic variation in the island populations compared to the mainland population. In contrast to the two measures of genetic variation, allele size variance and within-locus heterozygosity, the imbalance index (β) indicates evidence of recent expansion of population sizes in all islands and in the mainland. High mutation rates of the studied loci together with local drift effects are likely explanations for interisland genetic variation and the observed lack of reduced genetic diversity among the island populations.

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KW - D3SI358

KW - D5S818

KW - D7S820

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KW - Eastern Adriatic islands

KW - FGA

KW - Genetic variation

KW - Short tandem repeats

KW - TH01

KW - TPOX

KW - VWA

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AN - SCOPUS:28844504215

VL - 77

SP - 471

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JO - Human Biology

JF - Human Biology

SN - 0018-7143

IS - 4

ER -

Klarić IM, Peričić M, Lauc LB, Janićijević B, Kubat M, Pavičić D et al. Genetic variation at nine short tandem repeat loci among islanders of the eastern Adriatic coast of Croatia. Human Biology. 2005 Aug 1;77(4):471-486.