Genetic variation at nine short tandem repeat loci among islanders of the eastern Adriatic coast of Croatia

Irena Martinović Klarić, Marijana Peričić, Lovorka Barać Lauc, Branka Janićijević, Milovan Kubat, Dino Pavičić, Igor Rudan, Ning Wang, Lin Jin, Ranajit Chakraborty, Ranjan Deka, Pavao Rudan

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6 Scopus citations

Abstract

We have analyzed the extent of genetic variation at nine autosomal short tandem repeat loci (D3S1358, VWA, FGA, TH01, TPOX, CSF1PO, D5S818, D13S317, D7S820) among six populations from Croatia: five distributed in the islands of the eastern Adriatic coast and one from the mainland. The purpose is to investigate the usefulness of these loci in detecting regional genetic differentiation in the studied populations. Significant heterogeneity among the island and mainland populations is revealed in the distributions of allele frequencies; however, the absolute magnitude of the coefficient of gene differentiation is small but significant. The summary measures of genetic variation, namely, heterozygosity, number of alleles, and allele size variance, do not indicate reduced genetic variation in the island populations compared to the mainland population. In contrast to the two measures of genetic variation, allele size variance and within-locus heterozygosity, the imbalance index (β) indicates evidence of recent expansion of population sizes in all islands and in the mainland. High mutation rates of the studied loci together with local drift effects are likely explanations for interisland genetic variation and the observed lack of reduced genetic diversity among the island populations.

Original languageEnglish
Pages (from-to)471-486
Number of pages16
JournalHuman Biology
Volume77
Issue number4
DOIs
StatePublished - Aug 2005

Keywords

  • CSF1PO
  • Croatia
  • D13S317
  • D3SI358
  • D5S818
  • D7S820
  • Dalmatian islands
  • Eastern Adriatic islands
  • FGA
  • Genetic variation
  • Short tandem repeats
  • TH01
  • TPOX
  • VWA

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    Klarić, I. M., Peričić, M., Lauc, L. B., Janićijević, B., Kubat, M., Pavičić, D., Rudan, I., Wang, N., Jin, L., Chakraborty, R., Deka, R., & Rudan, P. (2005). Genetic variation at nine short tandem repeat loci among islanders of the eastern Adriatic coast of Croatia. Human Biology, 77(4), 471-486. https://doi.org/10.1353/hub.2005.0065