TY - JOUR
T1 - Genetic variation and population structure of interleukin genes among seven ethnic populations from Karnataka, India
AU - Raj, Srilakshmi M.
AU - Govindaraju, Diddahally R.
AU - Chakraborty, Ranajit
PY - 2007/12
Y1 - 2007/12
N2 - The extent of genetic variation and the degree of genetic differentiation among seven ethnic populations from Karnataka, India (Bunt, Havyak, Iyengar, Lingayath, Smartha, Vaishya, Vokkaliga), was investigated using four single nucleotide polymorphisms (SNPs: IL-1A 4845, IL-1B 3954, IL-1B 511 and IL-1RA 2018) of the interleukin gene cluster. Allele frequencies varied by threefold among these populations, which also differed for gene diversity and heterozygosity levels. The average degree of population subdivision among these castes was low (FST = 0.02). However, pair-wise interpopulation differentiation ranged from 0-7%, indicating no detectable differentiation to moderate differentiation between specific populations. The results of phylogenetic analysis based on genetic distances between populations agreed with known social and cultural data on these ethnic groups. Variation in the allele frequencies, as well as differentiation, may be attributed to differential selection and demographic factors including consanguinity among the ethnic groups. Information on the distribution of functionally relevant polymorphisms among ethnic populations may be important towards developing community medicine and public health policies.
AB - The extent of genetic variation and the degree of genetic differentiation among seven ethnic populations from Karnataka, India (Bunt, Havyak, Iyengar, Lingayath, Smartha, Vaishya, Vokkaliga), was investigated using four single nucleotide polymorphisms (SNPs: IL-1A 4845, IL-1B 3954, IL-1B 511 and IL-1RA 2018) of the interleukin gene cluster. Allele frequencies varied by threefold among these populations, which also differed for gene diversity and heterozygosity levels. The average degree of population subdivision among these castes was low (FST = 0.02). However, pair-wise interpopulation differentiation ranged from 0-7%, indicating no detectable differentiation to moderate differentiation between specific populations. The results of phylogenetic analysis based on genetic distances between populations agreed with known social and cultural data on these ethnic groups. Variation in the allele frequencies, as well as differentiation, may be attributed to differential selection and demographic factors including consanguinity among the ethnic groups. Information on the distribution of functionally relevant polymorphisms among ethnic populations may be important towards developing community medicine and public health policies.
KW - Ethnic variation
KW - Interleukin genes
KW - Karnataka
KW - Population structure
UR - http://www.scopus.com/inward/record.url?scp=40549101314&partnerID=8YFLogxK
U2 - 10.1007/s12041-007-0026-7
DO - 10.1007/s12041-007-0026-7
M3 - Article
C2 - 18305338
AN - SCOPUS:40549101314
SN - 0022-1333
VL - 86
SP - 189
EP - 194
JO - Journal of Genetics
JF - Journal of Genetics
IS - 3
ER -