Genetic composition of six miniSTR in a Brazilian Mulatto sample population

Xavier G. Aranda; Caroline A.C. Lage; John V. Planz; Arthur J. Eisenberg; Rodrigo S. Moura-Neto; Rosane Silva

doi:10.1016/j.jflm.2011.02.003

Genetic composition of six miniSTR in a Brazilian Mulatto sample population

Xavier G. Aranda, Caroline A.C. Lage, John V. Planz, Arthur J. Eisenberg, Rodrigo S. Moura-Neto, Rosane Silva

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The present study characterizes the genetic variability of Mulatto population based on the polymorphism of six miniSTR autosomal loci, known as Non Codis 01 and 02 (NC01 and NC02) and evaluate their applicability in forensic genetics. A sample of 102 unrelated Brazilian mulattoes were genotyped for miniSTR loci D1S1677, D2S441, D4S2364 (miniplex NC02) and 45 individuals for D10S1248, D14S1434, D22S1045 (miniplex NC01). No significant deviations from Hardy-Weinberg equilibrium expectations were detected. The combined power of discrimination (PD) and mean power of exclusion (PE) were 0.999996 and 0.98991, respectively. The results also support the effectiveness of the NC01and NC02 miniplexes for human identification.

Original language	English
Pages (from-to)	184-186
Number of pages	3
Journal	Journal of Forensic and Legal Medicine
Volume	18
Issue number	4
DOIs	https://doi.org/10.1016/j.jflm.2011.02.003
State	Published - May 2011

Keywords

Admixture
NCO 1
NCO 2
Non CODIS

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10.1016/j.jflm.2011.02.003

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title = "Genetic composition of six miniSTR in a Brazilian Mulatto sample population",

abstract = "The present study characterizes the genetic variability of Mulatto population based on the polymorphism of six miniSTR autosomal loci, known as Non Codis 01 and 02 (NC01 and NC02) and evaluate their applicability in forensic genetics. A sample of 102 unrelated Brazilian mulattoes were genotyped for miniSTR loci D1S1677, D2S441, D4S2364 (miniplex NC02) and 45 individuals for D10S1248, D14S1434, D22S1045 (miniplex NC01). No significant deviations from Hardy-Weinberg equilibrium expectations were detected. The combined power of discrimination (PD) and mean power of exclusion (PE) were 0.999996 and 0.98991, respectively. The results also support the effectiveness of the NC01and NC02 miniplexes for human identification.",

keywords = "Admixture, NCO 1, NCO 2, Non CODIS",

author = "Aranda, {Xavier G.} and Lage, {Caroline A.C.} and Planz, {John V.} and Eisenberg, {Arthur J.} and Moura-Neto, {Rodrigo S.} and Rosane Silva",

note = "Funding Information: This work was supported in part by research grants from Funda{\c c}{\~a}o Carlos Chagas de Amparo a Pesquisa – FAPERJ /Brasil (grants number: E26-112.168/2008 and E26-190.061/2008 ) and Conselho Nacional de Desenvolvimento Cient{\'i}fico e Tecnol{\'o}gico CNPq /Brazil, and National Institute of Justice /United States of America, grant number 2004-DN-BX-K212 (AJE). ",

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doi = "10.1016/j.jflm.2011.02.003",

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AU - Lage, Caroline A.C.

AU - Planz, John V.

AU - Eisenberg, Arthur J.

AU - Moura-Neto, Rodrigo S.

AU - Silva, Rosane

N1 - Funding Information: This work was supported in part by research grants from Fundação Carlos Chagas de Amparo a Pesquisa – FAPERJ /Brasil (grants number: E26-112.168/2008 and E26-190.061/2008 ) and Conselho Nacional de Desenvolvimento Científico e Tecnológico CNPq /Brazil, and National Institute of Justice /United States of America, grant number 2004-DN-BX-K212 (AJE).

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N2 - The present study characterizes the genetic variability of Mulatto population based on the polymorphism of six miniSTR autosomal loci, known as Non Codis 01 and 02 (NC01 and NC02) and evaluate their applicability in forensic genetics. A sample of 102 unrelated Brazilian mulattoes were genotyped for miniSTR loci D1S1677, D2S441, D4S2364 (miniplex NC02) and 45 individuals for D10S1248, D14S1434, D22S1045 (miniplex NC01). No significant deviations from Hardy-Weinberg equilibrium expectations were detected. The combined power of discrimination (PD) and mean power of exclusion (PE) were 0.999996 and 0.98991, respectively. The results also support the effectiveness of the NC01and NC02 miniplexes for human identification.

AB - The present study characterizes the genetic variability of Mulatto population based on the polymorphism of six miniSTR autosomal loci, known as Non Codis 01 and 02 (NC01 and NC02) and evaluate their applicability in forensic genetics. A sample of 102 unrelated Brazilian mulattoes were genotyped for miniSTR loci D1S1677, D2S441, D4S2364 (miniplex NC02) and 45 individuals for D10S1248, D14S1434, D22S1045 (miniplex NC01). No significant deviations from Hardy-Weinberg equilibrium expectations were detected. The combined power of discrimination (PD) and mean power of exclusion (PE) were 0.999996 and 0.98991, respectively. The results also support the effectiveness of the NC01and NC02 miniplexes for human identification.

KW - Admixture

KW - NCO 1

KW - NCO 2

KW - Non CODIS

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Genetic composition of six miniSTR in a Brazilian Mulatto sample population

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Keywords

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