TY - JOUR
T1 - Genetic components of variations of red cell glycolytic intermediates at two altitudes among the South American Aymara
AU - Chakraborty, R.
AU - Clench, Jocelyne
AU - Ferrell, R. E.
AU - Barton, Sara A.
AU - Schull, W. J.
N1 - Funding Information:
This research is funded through grants HL-15614, HL-05266 and GM 28574 from the US National Institutes of Health. To the residents of Northern Chile and Western Bolivia who participated in this study, as well as the field team who conducted the examinations and the Center for Demographic and Population Genetics staff who prepared the data for analysis, we express our gratitude. Thanks are also due to Dr Ronald N. Forthofer for making his MANOVA program available to us during the data analysis.
PY - 1983
Y1 - 1983
N2 - Red cell haemoglobin (Hb), haematocrit (Ht), 2,3-diphosphoglycerate (DPG), and adenosine triphosphate (ATP) levels were measured in 876 individuals from six villages at two altitude levels (altiplano and coast) of the Departmento de Arica of Northern Chile. Of these, data on 761 individuals are subjected to analysis to search for the evidence of genetic adaptation to a hypoxic environment at a high altitude. Total phenotypic variance for each of the variables is higher at the altiplano as compared to their counterparts at the coastal level. Data on 1127 pairs of relatives of six degrees of relationships are used to determine the genetic component of variation in each of these four traits. To a certain extent the larger familial correlations as well as higher variances at altiplano are explained by the apparent assortative mating (which may again be due to their restricted population size) at the higher elevation. Yet, at least in three variables (Hb, Ht, and DPG) no reduction in the additive genetic component of variation is noticed at the higher altitude. ATP seems to have the highest degree of genetic component of variance, particularly at the coastal level. Some implications of these results are discussed in the light of their roles in the glycolytic pathway.
AB - Red cell haemoglobin (Hb), haematocrit (Ht), 2,3-diphosphoglycerate (DPG), and adenosine triphosphate (ATP) levels were measured in 876 individuals from six villages at two altitude levels (altiplano and coast) of the Departmento de Arica of Northern Chile. Of these, data on 761 individuals are subjected to analysis to search for the evidence of genetic adaptation to a hypoxic environment at a high altitude. Total phenotypic variance for each of the variables is higher at the altiplano as compared to their counterparts at the coastal level. Data on 1127 pairs of relatives of six degrees of relationships are used to determine the genetic component of variation in each of these four traits. To a certain extent the larger familial correlations as well as higher variances at altiplano are explained by the apparent assortative mating (which may again be due to their restricted population size) at the higher elevation. Yet, at least in three variables (Hb, Ht, and DPG) no reduction in the additive genetic component of variation is noticed at the higher altitude. ATP seems to have the highest degree of genetic component of variance, particularly at the coastal level. Some implications of these results are discussed in the light of their roles in the glycolytic pathway.
UR - http://www.scopus.com/inward/record.url?scp=0020614233&partnerID=8YFLogxK
U2 - 10.1080/03014468300006311
DO - 10.1080/03014468300006311
M3 - Article
C2 - 6838163
AN - SCOPUS:0020614233
SN - 0301-4460
VL - 10
SP - 173
EP - 184
JO - Annals of Human Biology
JF - Annals of Human Biology
IS - 2
ER -