Genetic approaches to neurotrauma research: Opportunities and potential pitfalls of murine models

Oswald Steward, P. Elyse Schauwecker, Lloyd Guth, Ziyin Zhang, Minoru Fujiki, Denise Inman, Jean Wrathall, Gerd Kempermann, Fred H. Gage, Kathryn E. Saatman, Ramesh Raghupathi, Tracy McIntosh

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Abstract

Genetic strategies provide new ways to define the molecular cascades that regulate the responses of the mammalian nervous system to injury. Genetic interventions also provide opportunities to manipulate and control key molecular steps in these cascades, so as to modify the outcome of CNS injury. Most current genetic strategies involve the use of mice, an animal that has not heretofore been used extensively for neurotrauma research. Therefore, one purpose of the present review is to consider how mice respond to neural trauma, focusing especially on recent information that reveals important differences between mice and rats, and between different inbred strains of mice. The second aim of this review is to provide a brief introduction to the opportunities, caveats, and potential pitfalls of studies that use genetically modified animals for neurotrauma research.

Original languageEnglish
Pages (from-to)19-42
Number of pages24
JournalExperimental Neurology
Volume157
Issue number1
DOIs
StatePublished - May 1999

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    Steward, O., Schauwecker, P. E., Guth, L., Zhang, Z., Fujiki, M., Inman, D., Wrathall, J., Kempermann, G., Gage, F. H., Saatman, K. E., Raghupathi, R., & McIntosh, T. (1999). Genetic approaches to neurotrauma research: Opportunities and potential pitfalls of murine models. Experimental Neurology, 157(1), 19-42. https://doi.org/10.1006/exnr.1999.7040