TY - JOUR
T1 - Genetic approaches to neurotrauma research
T2 - Opportunities and potential pitfalls of murine models
AU - Steward, Oswald
AU - Schauwecker, P. Elyse
AU - Guth, Lloyd
AU - Zhang, Ziyin
AU - Fujiki, Minoru
AU - Inman, Denise
AU - Wrathall, Jean
AU - Kempermann, Gerd
AU - Gage, Fred H.
AU - Saatman, Kathryn E.
AU - Raghupathi, Ramesh
AU - McIntosh, Tracy
N1 - Funding Information:
The preparation of this review was supported by NIH Grant RO1NS 32280, O. Steward, P.I.
PY - 1999/5
Y1 - 1999/5
N2 - Genetic strategies provide new ways to define the molecular cascades that regulate the responses of the mammalian nervous system to injury. Genetic interventions also provide opportunities to manipulate and control key molecular steps in these cascades, so as to modify the outcome of CNS injury. Most current genetic strategies involve the use of mice, an animal that has not heretofore been used extensively for neurotrauma research. Therefore, one purpose of the present review is to consider how mice respond to neural trauma, focusing especially on recent information that reveals important differences between mice and rats, and between different inbred strains of mice. The second aim of this review is to provide a brief introduction to the opportunities, caveats, and potential pitfalls of studies that use genetically modified animals for neurotrauma research.
AB - Genetic strategies provide new ways to define the molecular cascades that regulate the responses of the mammalian nervous system to injury. Genetic interventions also provide opportunities to manipulate and control key molecular steps in these cascades, so as to modify the outcome of CNS injury. Most current genetic strategies involve the use of mice, an animal that has not heretofore been used extensively for neurotrauma research. Therefore, one purpose of the present review is to consider how mice respond to neural trauma, focusing especially on recent information that reveals important differences between mice and rats, and between different inbred strains of mice. The second aim of this review is to provide a brief introduction to the opportunities, caveats, and potential pitfalls of studies that use genetically modified animals for neurotrauma research.
UR - http://www.scopus.com/inward/record.url?scp=0032933945&partnerID=8YFLogxK
U2 - 10.1006/exnr.1999.7040
DO - 10.1006/exnr.1999.7040
M3 - Review article
C2 - 10222106
AN - SCOPUS:0032933945
SN - 0014-4886
VL - 157
SP - 19
EP - 42
JO - Experimental Neurology
JF - Experimental Neurology
IS - 1
ER -