TY - JOUR
T1 - Genetic and environmental risk factors for childhood eczema development and allergic sensitization in the CCAAPS cohort
AU - Biagini Myers, Jocelyn M.
AU - Wang, Ning
AU - Lemasters, Grace K.
AU - Bernstein, David I.
AU - Epstein, Tolly G.
AU - Lindsey, Mark A.
AU - Ericksen, Mark B.
AU - Chakraborty, Ranajit
AU - Ryan, Patrick H.
AU - Villareal, Manuel S.
AU - Burkle, Jeff W.
AU - Lockey, James E.
AU - Reponen, Tiina
AU - Khurana Hershey, Gurjit K.
N1 - Funding Information:
This study was supported by National Institute for Environmental Health Sciences grant numbers R01 ES11170 and T32 ES10957. We thank the participating families for continuing to be involved in the study and for welcoming us into their homes, as well as the clinical, exposure, recruitment, and retention study staff.
PY - 2010/2
Y1 - 2010/2
N2 - Eczema is very common and increasing in prevalence. Prospective studies investigating environmental and genetic risk factors for eczema in a birth cohort are lacking. We evaluated risk factors that may promote development of childhood eczema in the Cincinnati Childhood Allergy and Air Pollution Study (CCAAPS) birth cohort (n762) of infants with at least one atopic parent. Objective environmental exposure data were available for each participant. At annual physical examinations, children underwent skin prick tests (SPTs), eczema was diagnosed by a clinician, and DNA was collected. Among Caucasian children, 39% developed eczema by age 3. Children with a pet dog were significantly less likely to have eczema at age one (odds ratio (OR)0.62, 95% confidence interval (CI): 0.40-0.97) or at both ages 2 and 3 (OR0.54, 95% CI: 0.30-0.97). This finding was most significant among children carrying the CD14-159C/T CC genotype. Carriers of the CD14-159C/T and IL4Rα I75V single-nucleotide polymorphisms (SNPs) had an increased risk of eczema at both ages 2 and 3 (OR3.44, 95% CI: 1.56-7.57), especially among children who were SPT. These results provide new insights into the pathogenesis of eczema in high-risk children and support a protective role for early exposure to dog, especially among those carrying the CD14-159C/T SNP. The results also demonstrate a susceptibility effect of the combination of CD14 and IL4Rα SNPs with eczema.
AB - Eczema is very common and increasing in prevalence. Prospective studies investigating environmental and genetic risk factors for eczema in a birth cohort are lacking. We evaluated risk factors that may promote development of childhood eczema in the Cincinnati Childhood Allergy and Air Pollution Study (CCAAPS) birth cohort (n762) of infants with at least one atopic parent. Objective environmental exposure data were available for each participant. At annual physical examinations, children underwent skin prick tests (SPTs), eczema was diagnosed by a clinician, and DNA was collected. Among Caucasian children, 39% developed eczema by age 3. Children with a pet dog were significantly less likely to have eczema at age one (odds ratio (OR)0.62, 95% confidence interval (CI): 0.40-0.97) or at both ages 2 and 3 (OR0.54, 95% CI: 0.30-0.97). This finding was most significant among children carrying the CD14-159C/T CC genotype. Carriers of the CD14-159C/T and IL4Rα I75V single-nucleotide polymorphisms (SNPs) had an increased risk of eczema at both ages 2 and 3 (OR3.44, 95% CI: 1.56-7.57), especially among children who were SPT. These results provide new insights into the pathogenesis of eczema in high-risk children and support a protective role for early exposure to dog, especially among those carrying the CD14-159C/T SNP. The results also demonstrate a susceptibility effect of the combination of CD14 and IL4Rα SNPs with eczema.
UR - http://www.scopus.com/inward/record.url?scp=75549090440&partnerID=8YFLogxK
U2 - 10.1038/jid.2009.300
DO - 10.1038/jid.2009.300
M3 - Article
C2 - 19759553
AN - SCOPUS:75549090440
SN - 0022-202X
VL - 130
SP - 430
EP - 437
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
IS - 2
ER -