TY - JOUR
T1 - Genetic admixture in three Mexican Mestizo populations based on D1S80 and HLA-DQA1 loci
AU - Cerda-Flores, Ricardo M.
AU - Villalobos-Torres, Maria C.
AU - Barrera-Saldaña, Hugo A.
AU - Cortés-Prieto, Lizette M.
AU - Barajas, Leticia O.
AU - Rivas, Fernando
AU - Carracedo, Angel
AU - Zhong, Yixi
AU - Barton, Sara A.
AU - Chakraborty, Ranajit
PY - 2002
Y1 - 2002
N2 - This study compares genetic polymorphisms at the D1S80 and HLA-DQA1 loci in three Mexican Mestizo populations from three large states (Nuevo León, Jalisco, and the Federal District). Allele frequency distributions are relatively homogenous in the three samples; only the Federal District population shows minor differences of the HLA-DQA1 allele frequencies compared with the other two. In terms of genetic composition, these Mestizo populations show evidence of admixture with predominantly Spanish-European (50-60%) and Amerindian (37-49%) contributions; the African contribution (1-3%) is minor. Together with the observation that in Nuevo León, the admixture estimates based on D1S80 and HLA-DQA1, are virtually the same as those reported earlier from blood group loci, suggests that DNA markers, such as D1S80 and HLA-DQA1 are useful for examining genetic homogeneity/heterogeneity across Mestizo populations of Mexico. The inverse relationship of the proportion of gene diversity due to population differences (Gst) to within population gene diversity (Hs) is also consistent with theoretical predictions, supporting the use of these markers for population genetics studies. Am. J. Hum. Biol. 14:257-263, 2002.
AB - This study compares genetic polymorphisms at the D1S80 and HLA-DQA1 loci in three Mexican Mestizo populations from three large states (Nuevo León, Jalisco, and the Federal District). Allele frequency distributions are relatively homogenous in the three samples; only the Federal District population shows minor differences of the HLA-DQA1 allele frequencies compared with the other two. In terms of genetic composition, these Mestizo populations show evidence of admixture with predominantly Spanish-European (50-60%) and Amerindian (37-49%) contributions; the African contribution (1-3%) is minor. Together with the observation that in Nuevo León, the admixture estimates based on D1S80 and HLA-DQA1, are virtually the same as those reported earlier from blood group loci, suggests that DNA markers, such as D1S80 and HLA-DQA1 are useful for examining genetic homogeneity/heterogeneity across Mestizo populations of Mexico. The inverse relationship of the proportion of gene diversity due to population differences (Gst) to within population gene diversity (Hs) is also consistent with theoretical predictions, supporting the use of these markers for population genetics studies. Am. J. Hum. Biol. 14:257-263, 2002.
UR - http://www.scopus.com/inward/record.url?scp=18344389032&partnerID=8YFLogxK
U2 - 10.1002/ajhb.10020
DO - 10.1002/ajhb.10020
M3 - Article
C2 - 11891937
AN - SCOPUS:18344389032
SN - 1042-0533
VL - 14
SP - 257
EP - 263
JO - American Journal of Human Biology
JF - American Journal of Human Biology
IS - 2
ER -