TY - JOUR
T1 - General health status and adherence to antiretroviral therapy
AU - Cardarelli, Roberto
AU - Weis, Stephen
AU - Adams, Elvin
AU - Radaford, Debbie
AU - Vecino, Isabel
AU - Munguia, Guadalupe
AU - Johnson, Katandria Love
AU - Fulda, Kimberly G.
PY - 2008/5
Y1 - 2008/5
N2 - Highly active antiretroviral therapy (HAART) adherence is crucial in lowering HIV/AIDS-related mortality. General health status is known to predict mortality, but no study has assessed its association with HAART adherence. A total of 103 whites, African Americans, and Hispanic/Latinos with HIV/AIDS underwent an interview using validated measures. Regression analyses assessed the relationship between general health status and HAART adherence while controlling for social support, sense of control, depression, stress, HIV stigma, substance abuse, and unfair treatment because of race. Those rating their general health as fair/poor were 4 times more likely to be nonadherent (odds ratio [OR], 4.34; 95% confidence interval [CI], 1.19-15.79). This association dramatically strengthened in the multivariate regression model (OR, 10.96; 95% CI, 1.46-82.36) after controlling for the covariates. Conclusion: General health status was the strongest predictor of HAART nonadherence, and future research is needed to assess whether this 1-question general health measure can be clinically used to influence adherence.
AB - Highly active antiretroviral therapy (HAART) adherence is crucial in lowering HIV/AIDS-related mortality. General health status is known to predict mortality, but no study has assessed its association with HAART adherence. A total of 103 whites, African Americans, and Hispanic/Latinos with HIV/AIDS underwent an interview using validated measures. Regression analyses assessed the relationship between general health status and HAART adherence while controlling for social support, sense of control, depression, stress, HIV stigma, substance abuse, and unfair treatment because of race. Those rating their general health as fair/poor were 4 times more likely to be nonadherent (odds ratio [OR], 4.34; 95% confidence interval [CI], 1.19-15.79). This association dramatically strengthened in the multivariate regression model (OR, 10.96; 95% CI, 1.46-82.36) after controlling for the covariates. Conclusion: General health status was the strongest predictor of HAART nonadherence, and future research is needed to assess whether this 1-question general health measure can be clinically used to influence adherence.
KW - HAART
KW - adherence
KW - self-rated health
KW - social support
UR - http://www.scopus.com/inward/record.url?scp=59049097867&partnerID=8YFLogxK
U2 - 10.1177/1545109708318526
DO - 10.1177/1545109708318526
M3 - Article
C2 - 18441253
AN - SCOPUS:59049097867
SN - 1545-1097
VL - 7
SP - 123
EP - 129
JO - Journal of the International Association of Physicians in AIDS Care
JF - Journal of the International Association of Physicians in AIDS Care
IS - 3
ER -